I believe that entocort is more "topical" vs. systemic (lower side effects). I also recall learning that it works best near the end of the the small intestine, the terminal ilium and only the right side of the large intestine, so not really beneficial if the bulk of the disease is left sided. I think it works better for Crohn's than UC.
My son has left sided UC and entocort did not help him at all, symptoms progressed while he was on it.
Mom of Son 17 UC dx 07/02, Prednisone 30mg, Lailda 2 am & 2 pm, Azasan 100mg, Cortafoam (when flaring), folic acid, L. Reuteri, Culturelle, Zyrtec, Iron, Vit/Min
Daughter 10 UC dx 08/07 Prednisone 10mg am & 10mg pm, Colazal 750mg x 4, 6MP 25mg, Iron, Vit/Min., Culturelle