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Regular Member

Date Joined Feb 2009
Total Posts : 402
   Posted 7/8/2009 9:49 AM (GMT -6)   
I ache all over and have been for the past few days, its worse as the day gets on.
I suffer the fatigue that comes with Colitis...and thats obviously tiredness aswell as general lethargy. My concern is - could this be the Prednisolone causing the aching, as it feels different from the usual lethargy/tiredness? I've been on varying doses of Pred for the past 6 months and am trying to taper off, without success. I'm worried it may have begun affecting my joints. confused
22 year old female, from the UK. Diagnosed with Ulcerative Proctitis Jan '08. Hospitalised Jan '09 for 3 days IV Hydrocortisone - had no effect! Hospitalised Feb '09 for 7 days (5 days - IV Hydrocortisone)
Currently taking daily: 
15mg Prednisolone tablets (tapering), 100mg Azathioprine (started taking 11th May),1g Acetarsol suppository, Asacol suppository (alternating nights)1g Mesalazine granules x 2 
Motilium (anti sickness), 1.5mg Zopiclone (taken when needed for sleeping), 10mg Citalopram (anti-anxiety), Probiotic Multivitamins, Nutren Build up drinks. 

Regular Member

Date Joined Mar 2008
Total Posts : 113
   Posted 7/8/2009 1:01 PM (GMT -6)   
I started aching when I got down to 20mgs of Pred. I had horrific knee pain the 2nd night of tapering to 20mg, then it slowed down, then this week i had it again when tapering to 15mg. I think it's part of your adrenal glands trying to adjust. if it keeps up and is unbearable you may want to taper more slowly.
Diagnosed w/ UC in August 2007
Was in remission for almost one year (using only Lialda 4xday)
Rowasa and Canasa did not work.
Current status: In Remission since June 2009

4 Lialda/day maintenance, healthy diet
Starting Colal-Pred trial May 18, 2009, ended when hospitalized two weeks later. Also diagnosed with C. Diff while in hospital.
Currently taking 20mg Prednisone (tapering).

Regular Member

Date Joined Mar 2009
Total Posts : 33
   Posted 7/9/2009 8:18 AM (GMT -6)   
Some say Prednisolone causes aching but I have really noticed it since I tapered off Pred and moved on to Imuran (125mg). All my joints ache and it feels really bad when I wake up. Many others complain of Arthritis like conditions. I see specialist on 27th July so will ask question and see if there is any way to combat aching joints without letting the stomach pains return.
UC first diagnosed 2007.
Asacol 3 tabs twice a day / Predisolone 20mg, 15mg, 10mg 5 mg
Flare-up Jan 2009 used Prednisolone came off it then had major flare up and developed gout.
Colonoscopy March 2009 reveals Severe Pancolitis.
Asacol 4 tabs twice a day / Prednisolone 40mg 2 weeks, 35mg 2 weeks
then start Azathioprine.
June 2009 125mg Azathioprine plus Asacol 4 x 2  UC has cleared up completely but boy do my joints ache.

Veteran Member

Date Joined May 2008
Total Posts : 574
   Posted 7/9/2009 11:37 AM (GMT -6)   
I have been really aching since coming of pred my legs more so they feel heavy to move sometimes.
  Diagnosed 22.5.08 with Lft sided U/C
  Meds Predfoam 20mg 2x day stopped started pentasa supps 1gm 26/6/08
 Asacol 800mg x2 twice daily
  Domperidone 10mg as needed
  co codamol 30/500 x2 when needed
  Asacol foam 2g nightly 19/3/09
  Prednisone 60mg 19/3/09 tappering after2wks

Veteran Member

Date Joined Mar 2008
Total Posts : 2855
   Posted 7/9/2009 12:10 PM (GMT -6)   
I never noticed aching from prednisone (although I did get muscle cramps). It might be anemia you are experiencing, or some other chemical imbalance.
49 year old female attorney, diagnosed UC/pancolitis 1985, no surgery but much suffering. Asacol maintenance for 20+ years; used prednisone & Rowasa for flares.  Probiotics (Ultimate Flora, 50 billion), salmon oil (omega-3) when I can remember. 
August 2008 sought care of naturopathic doctor. Food sensitivity test showed wheat/gluten, other intolerances; eliminated wheat/gluten from my diet.
Bad flare in March, used prednisone. Humira denied, started Remicade 4/12 and doing great~ learning what normal is~ wow

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