I've only used mesalamine enemas; I've never used suppositories. I find the enemas quick and easy to administer, and haven't had any trouble holding them in like others have. Suppositories are supposedly easier. When I was flaring, I used an enema every night. Once I got into remission, I went to every other night, then to twice a week (Sunday and Thursday nights).
Status: Remission since late May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently taking Apriso (4 pills ONCE!! daily), Rowasa twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (25 mg).