When 6mp fails...

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Regular Member

Date Joined Jul 2008
Total Posts : 35
   Posted 7/15/2009 1:00 PM (GMT -6)   
I have been on 6mp for 6 months and it is not working at all.  I have another appointment next week.  The only thing that did work for me was prednisone but we all know that is only short term relief and the side effects were Awful!!  I am really disappionted 6mp isnt working.  I just dont get it.  I had to recently reduce the dosage 75 mg down from 100mg due to too low of white blood count.  My question is what is next?  Are there any UC'ers out there that 6mp did not work and where did you go from here?  I am currently taking colazal 9X day, canasa 2X day, then 6mp 75 mg.  I go 6, 7, or 8 times a day...  Thanks for listening.

Veteran Member

Date Joined Feb 2009
Total Posts : 7150
   Posted 7/15/2009 1:01 PM (GMT -6)   
There's still the option of Remicade, so long as you're in a country (like the US) that it's approved for use in. There are quite a few people on here who use it and have had a lot of success with it.
Status: Remission since late May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently taking Apriso (4 pills ONCE!! daily), Rowasa twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (25 mg).

Veteran Member

Date Joined Aug 2008
Total Posts : 5975
   Posted 7/15/2009 3:35 PM (GMT -6)   
     Hi Britney.  I have been on 6MP for over six years and I believe it has stopped working.  That is, even if it ever started.  My flare started around Memorial Day after only enjoying a seven month remission.  The doctor started me at 20 mgm of prednisone but that NEVER does anything.  So he finally increased the dose to 40 mgm a week ago.  He also increased the 6MP to 100 mgm.  I am NOT happy at all with this dose.  I feel extremely fatigued.  My last white count (done two weeks ago) was 3.1 but my red count is also down.  My B12 level is normal.  Now my bilirubin is slightly elevated and today I had to go for a liver panel test.  Geez, if the disease doesn't kill  ya these meds sure will!  I also am on Cort enemas nightly and Canasa in the morning.  My SCD bood arrived in the mail today.  Guess I will give that a shot.  I have an appointment with my GI doctor a week from tomorrow.  He said I am at the limit where he is able to help me and my next step is to see a specialist at the Univ of Pa Hospital.  I cannot take Remicade because I was exposed to the TB virus back in the 60's.  So I suppose the next step is to remove my rectum because that is where my UC is located.  Oddly, but I suppose gratefully, in the eleven years I have suffered with this, it has never traveled further into my colon.  However, it is extremely painful.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Meds as of June 09: Colazal (6 per day), 6MP (50 mgm), Probiotic (upped to 3 per day), Fish oil capsule, calcium, multivitamin, Cort enema nightly, Canasa in morning.  Also taking Benicar and Toprol to control high blood pressure.  Getting old is a b****.

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