Colitis long term treatment?

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New Member

Date Joined Jul 2009
Total Posts : 7
   Posted 7/16/2009 4:42 AM (GMT -6)   
Does anyone know what is best for long term maintenance of Proctitis (colitis of the rectum)? I was thinking either mesalamine rectal suppositories or mesalamine oral tablets. I am not sure which would be best for long term treatment... Prior to this I had only been using suppositories whenever I had a flareup, but I recently found out that I should be applying constant treatment every day (even when I am in remission) to prevent future flares and to maintain remission. So I have two options, oral tablets or rectal suppositories... but I am not sure which one I should be using every single day. Does anyone have any thoughts about this?

Veteran Member

Date Joined Mar 2009
Total Posts : 1439
   Posted 7/16/2009 9:16 AM (GMT -6)   
If it's confined to the rectum, I'd think the suppositories would be more effective, as mesalamine oral tablets start getting released in the ileum, where the suppositories are localized to the rectum, so you get a stronger dose at the effected site. You may want to take the tablets as well, though (as quincy would say, treat from both ends!)
21, female, diagnosed 3/6/2009
Mild ulcerative colitis from rectum to mid transverse colon
Currently taking Asacol (3x/day) and Calcium/D supplements

Veteran Member

Date Joined Feb 2009
Total Posts : 7150
   Posted 7/16/2009 10:10 AM (GMT -6)   
I think that enemas or suppositories would be the most beneficial, but I agree with Malkavian that an oral mesalamine couldn't hurt either.
Status: Remission since late May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently taking Apriso (4 pills ONCE!! daily), Rowasa twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (25 mg).

Veteran Member

Date Joined Aug 2008
Total Posts : 5975
   Posted 7/16/2009 12:28 PM (GMT -6)   
     I've had UP for over ten years.  The doctor had me on Colazal for maintenance treatment...didn't keep me in remission.  Also was on 6MP, 50 mgm....nada.  Now in a flare, so on 35 mgm of prednisone, 100 mgm of 6MP, Cort enemas, Colazal and Canasa..ugh.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Meds as of June 09: Colazal (6 per day), 6MP (50 mgm), Probiotic (upped to 3 per day), Fish oil capsule, calcium, multivitamin, Cort enema nightly, Canasa in morning.  Also taking Benicar and Toprol to control high blood pressure.  Getting old is a b****.

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