6MP Questions...

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Regular Member

Date Joined Jul 2009
Total Posts : 32
   Posted 7/22/2009 10:46 AM (GMT -6)   
For anyone who has been on 6MP, how long does it take to start working?  I know that the doctors say 3-6 months but would like to hear from any of you.  Started about a week ago and am already experiencing hair loss...

Post Edited By Moderator (Lonie) : 7/22/2009 9:56:58 AM (GMT-6)

Regular Member

Date Joined Nov 2008
Total Posts : 33
   Posted 7/22/2009 1:10 PM (GMT -6)   

I have been on 6mp for nearly 9 months and have seen some improvements, but my dose had to be moved up to 150mg before I noticed any benefit. At 150 mg/day I had to break up my dose and take it 50mg in the morning then 100mg at night. I too noticed some hair loss, but that has been pretty minimal. Unfortunately as my profile shows I had to go back on Pred, so it looks like 6mp is not my drug so it may be on to Remicade next. Hopefully it will work well for you.

Dx'd June 08 severe UC (pancolitis), symptoms for years before dx
30 yrs old
Asacol 400mg x 12, Prednisone 40mg tapering off now
Prednisone 40mg again
6-mp 100mg moved to 6-mp 150mg, Canasa
Probiotics x3/day, Ominvite Multivitamin x3/day
Approved for Remicade, waiting for 6mp to fail me

Veteran Member

Date Joined Aug 2008
Total Posts : 5975
   Posted 7/22/2009 1:30 PM (GMT -6)   
     Been on 6MP for almost six years.  I was on 50 mgm but experienced my second flare in less than a year in remission.   My GI increased my dosage to 100 mgm on June 11th.  I am on 30 mgm of prednisone and tapering by 5mgm weekly.  Bleeding is gone, still have some pain in rectum.  My main problem is ulcerative proctitis.  I also take Colazal, Cort enemas nightly and Canasa suppository in a.m.
     I have experienced some thinning of the hair, but try Nioxin.  It works wonders!  You can purchase it the hair dressers.  6MP does take anywhere from three to six months to "kick in" along with the prednisone.  However, it has NOT kept me out of flares.
     I am not a candidate for Remicade because I was exposed to the TB virus years ago while working in a hospital lab and the Remicade could activate the TB.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Meds as of June 09: Colazal (6 per day), 6MP (50 mgm), Probiotic (upped to 3 per day), Fish oil capsule, calcium, multivitamin, Cort enema nightly, Canasa in morning.  Also taking Benicar and Toprol to control high blood pressure.  Getting old is a b****.

Regular Member

Date Joined Jul 2009
Total Posts : 32
   Posted 7/22/2009 1:42 PM (GMT -6)   
Thanks UCdad.  I'm going to a nutritionist next week to see if that will help.  It's expensive but I am feeling awful and can't leave the house to go to work until 10AM every morning.  Have you ever considered a nutritionist?

Regular Member

Date Joined Jan 2009
Total Posts : 307
   Posted 7/22/2009 7:34 PM (GMT -6)   
I started on 6mp just about 3 months ago and have been on Prednisone since May 22nd (finishing my dose in a week).  I havnent seen any improvments from the 6mp at all.  I started on 50mg and then jumped to 100mg within a month.  I had to get off of the 100mg because the side affects were so hard to deal with.  I'm most likely going to give it another month and if doenst work, Remicade here I come.
Age: 25 / Male / Florida
Diagnosed: 11/08 / Pancolitis
Diagnosed with PSC: 3/9 --now taking Urso
Asacol - 2 x 3 day (waiting for results)
6MP - 50mg - 5/04/09 - 100mg - started 6/11/09 - back to 50mg 7/8/09
Mens Multi Vitamin - 1 a day
Vitamin A Deficient - 10,000mg a day
Calcium & Vitamin D3 - 1200mc of Calcium and 800iu of Vitamin D3  
Jaro - Dophilus Probiotic (3.4 Billion) - 1 a day
~~~Praying for a cure~~~~

Regular Member

Date Joined Jul 2009
Total Posts : 32
   Posted 7/22/2009 7:48 PM (GMT -6)   
What were your side effects?

Liza D
Regular Member

Date Joined Apr 2009
Total Posts : 166
   Posted 7/22/2009 9:46 PM (GMT -6)   
It took me a while. I think I was taking my Asacol with the 6MPs for about 3 months before we started to taper. But again, I feel like the meds never worked for me anyway. Good Luck and keep up with the blood work. That is the best way for the docs to track your immune system.
UC (Pancolitis... 90%!) December 2001
Arthritis (2003)
Upper GI Ulcer (2006)
Osteopenia (2008)
Depression/Anxiety (2002)
J-Pouch May 2009

Check out my blog: shlookshlies.blogspot.com/

Regular Member

Date Joined Jul 2009
Total Posts : 32
   Posted 7/22/2009 10:07 PM (GMT -6)   
Thanks.  I'm going to a nutritionist to see what she says.  Have you tried that route?

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 7/23/2009 8:08 AM (GMT -6)   
I have been on 6mp for almost 3 years. I started noticing a difference around 7 weeks but I didn't get the full effect until about the 3 month mark. The hair loss is temporary. I loss massive amounts of hair but after a while (maybe 2 months or so?) it stopped. I was also extremely tired, slightly nauseas and I had a lot of headaches when I first started it. Now I don't get any of those side effects. I still get tired on occasion but I don't know if it's the meds or the UC that is causing my fatigue.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate ALL mesalamines**~Allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis~bulging and herniated discs C5/C6 & C6/C7~Epidural injections (2 series of 3), OA-Celebrex, Tylonel Arthritis and Voltaren Gel
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Regular Member

Date Joined Feb 2009
Total Posts : 402
   Posted 7/23/2009 10:08 AM (GMT -6)   
I've been on Azathioprine for nearly 10 weeks, I noticed side effects within days of taking it but it is not having any noticeable affect on my UC yet.

23 year old female from the UK. Diagnosed with Ulcerative Proctitis Jan '08. Hospitalised Jan '09 for 3 days; Hospitalised Feb '09 for 7 days.
Currently taking daily: 
(Just finished course of Prednisolone), 100mg Azathioprine, Asacol suppository 500mg, 1g Mesalazine granules x 2 
Motilium (anti sickness), 1.5mg Zopiclone (taken when needed for sleeping), 10mg Citalopram (anti-anxiety), Probiotic Multivitamins.

Regular Member

Date Joined Jun 2009
Total Posts : 173
   Posted 7/23/2009 10:14 AM (GMT -6)   
I have taken 175 mg of azathioprine for the last 6 years. I started it while on a full dose of prednisone and by the time I tapered off that the azathioprine had kicked in (I assume) and I was in remission. So that would have been a few months. I have never noticed any side effects. I do get hair loss occasionally but that seems to coincide more with tapers off of prednisone. I credit azathioprine with keeping me in remission for 3 years, so I hope it works for you as well!
UC since 1996 (age 20)
Mommy of 2 sweet little girls.
My life is one big flare.

Asacol, Azathioprine, Prednisone, Rowasa
First Remicade 6/22/09

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