GI wants to increase 6MP already?

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Regular Member

Date Joined Dec 2008
Total Posts : 199
   Posted 7/30/2009 7:46 PM (GMT -6)   
I've been on 6MP for only about 2 weeks. My GI thinks this is a good enough indication after my blood work(too high WBC count) to increase my dosage to 100 mg. I thought it takes about 6 months for 6MP to totally kick in, why should I already increase my dosage?
Asacol-12 a day
1 Culturelle
1 Canasa
5g Fish oil supplements
1 Vitamin
50 mg 6MP
Gluten-free and lactose-free diet

Forum Moderator

Date Joined Apr 2004
Total Posts : 23551
   Posted 7/31/2009 6:01 AM (GMT -6)   
Different GI's use different protocols when increasing. My GI was conservative with the increase approach. He started me on 25mgs to see if I could tolerate it. After 2 blood draws he increased it to 50mgs. I stayed at 50mgs for quite a while until I wouldn't stop flaring then he increased 2 of my days to 100mgs. So if you have any questions about how fast he is moving, maybe you should ask him for clarification.
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Regular Member

Date Joined May 2008
Total Posts : 191
   Posted 7/31/2009 6:47 AM (GMT -6)   
I started Imuran at 50 mg and then a couple weeks later went up to 100 mg. My doc did that because the 50 didn't do much, and with my weight he figured why the hell not?
22 years old

Diagnosed with moderate/severe UC June 2007, I've had it since December 2006.

Haven't been on here in a while (finally graduated college).
Update as of 5/26/09 - Now taking Imuran 100mg/day.
2 Lialda/day.
Vitamins - Caltrate+D, iron, A, B12,
Flintstone Complete+iron, and aloe vera pills/juice.
At least I'm off the Entocort. =]

Veteran Member

Date Joined Aug 2008
Total Posts : 5951
   Posted 7/31/2009 6:56 AM (GMT -6)   
     My GI had me on 50 mgm of 6MP but my white count went up to 4.0 (normal limit) and I started a flare.  He started me on 30 mgm of prednisone but that did nothing, so he increased the prednisone to 40 mgm with a 5 mgm per week taper and increased the 6MP to 100 mgm.  This was the 11th of June.  I also take nine Colazal capsules per day, Cort enema in the evening and Canasa suppository in the morning.  I experienced about four episodes of very bad heart burn....felt like someone punched me in the upper stomach and pain radiated into my back.  All four times I was sitting here at the computer.  Relief came when I stood up and walked a bit.  The doctor then told me to take Nexium every morning and this has given me great relief.
     The only thing I don't like about this increase in dosage of the 6MP is that I feel very tired and have a metallic taste in my mouth.  I've been on 6MP (never this high of a dose) for six years.  I have ulcerative proctitis and (keeping my fingers crossed) am starting to go into blood, formed bowel movements and no urgency or pain the last few days.
     My bilirubin was a bit high and yesterday I had an ultrasound of the liver, pancreas and gall bladder to rule out any underlying problem as to the upper gastric distress.  Next week I go for tons of blood tests...soooo, we'll see.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Meds as of June 09: Colazal (6 per day), 6MP (50 mgm), Probiotic (upped to 3 per day), Fish oil capsule, calcium, multivitamin, Cort enema nightly, Canasa in morning.  Also taking Benicar and Toprol to control high blood pressure.  Getting old is a b****.

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