Article about IBD meds and Opportunistic Infections

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Jen O
Regular Member


Date Joined May 2009
Total Posts : 136
   Posted 8/4/2009 7:51 PM (GMT -6)   
Hey you guys!

I thought you might be interested in this article that I came across. Maybe we aren't as prone to infections as we thought.

http://www.medscape.com/viewarticle/706173?src=mp&spon=17&uac=35238FZ

Jen
Age 34, Diagnosed with UC September 2008
Current Meds:
Started Azathioprine 100 mgs 6/22/2009 and Apriso 4 tabs daily 6/11/2009
Biotin 5 mg
Vitamin D 2,000 IU per day
Calcium 1500 mg per day
Flaxseed Oil 2000 mg per day
Multivitamin
Also tried: Remicade, Asacol, Rowasa, Cantasa, Prednisone 2 times for about 3 months each


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 8/4/2009 8:06 PM (GMT -6)   
Jen, I think most of us can't get to the article because we aren't subscribers. Perhaps you could summarize the findings for us?
Judy
 
Ulcerative colitis forum co-moderator
 
Moderate to severe left-sided UC diagnosed 2001.
Flared for 5 years, finally in remission with Remicade since March 2006.
Avascular necrosis in both shoulders is my "forever" gift from steroids.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. 
"My life is an ongoing medical adventure"
 


Jen O
Regular Member


Date Joined May 2009
Total Posts : 136
   Posted 8/4/2009 8:18 PM (GMT -6)   
Whoops, Sorry, I forgot about the subscription.

In summary:
The researchers found that "other immusupressive agents" (azathioprine, mercaptopurine and methotrexate) had a rate of 3.8 serious infections per 1000 person-years, Infliximab (Remi) had a rate of 7.4 serious infections per 1000 person-years.

0/1000 Remi infusions (actually 521 infusions) had patients that got c-diff infections. BUT 14/1000 person-years of people on corticosteriods got c-diff.

To quote the article "In a population-based cohort of patients with IBD, we found no meaningful association between infliximab and serious bacterial infections, although some subgroups had few events. Corticosteroid initiation increased the risk for C. difficile infections in these patients"

It's hard to summarize, so I hope I did a good job.
Jen
Age 34, Diagnosed with UC September 2008
Current Meds:
Started Azathioprine 100 mgs 6/22/2009 and Apriso 4 tabs daily 6/11/2009
Biotin 5 mg
Vitamin D 2,000 IU per day
Calcium 1500 mg per day
Flaxseed Oil 2000 mg per day
Multivitamin
Also tried: Remicade, Asacol, Rowasa, Cantasa, Prednisone 2 times for about 3 months each

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