As far as I know, it doesn't matter, unless it upsets your stomach...if so, take it with a meal. I take my Apriso with breakfast, just b/c it's easy to remember then.
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently taking Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (25 mg).