mesalazine vs sulphasalazine

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Regular Member

Date Joined Mar 2009
Total Posts : 40
   Posted 8/11/2009 5:36 PM (GMT -6)   
hello everybody :)
haven't been for a while cause felt rather good, no flare for almost a year if not count a pair of times of seeing blood... and still feeling good if talking about UC. But some 2 months ago out of the blue I got some reumatic fever, in 15 minutes I felt completely immobile, I could not move my knees, then my feet6 and finally I could not move at all. Next morning I managed to see a rheumatologist, and she found my CRP was 58 and lots of liquid in my knees. She said it was not rheumatic arthrytis, but could not diagnose what was that and came to the conclusion that this must be a result of UC. She prescribed Piroxicamum, I am taking it from time to time, when it gets worse and it seems to help at the time, but the condition still repeats, not anymore that bad, but bad enough. And she, the rheumatologist said that most probably I will have to reconsider and to go on sulphasalazine instead of mesalazine for a few years, as she never heard that both of them could be taken, and that both of them are very similar just sulphasalazine works more on joints and mesalazine more on intestine. So I am really confused now, as I tolerate mesalazine really well and it does help me, and I am afraid that UC could return on flare if I change my medications. Have anyone heard about combining these two meds and if sulphasalazine could really help me with UC? And about such condition, what that might be? I prefer staying on mesalazine, but I have no idea how my joints condition might progress if I not change my medications. Or maybe there are some other medications, for both conditions? Any ideas, please share:)
Female, 48
symptoms including bleeding since 2002, UC diagnosed in 2006
Sulfalazine 750mg tabs 3x daily (tapered from 1000mg 4x)
Iron, fish oil, probiotics, other supplements
Colonoscopies: 2
on Remission since Sept'08 after almost 1 year flare

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 8/12/2009 6:57 AM (GMT -6)   
You might want to ask these same questions on our arthritis boards. Many IBD'ers frequent those boards as well. I have heard of Sulfasalazine being used to treat arthritis but not sure about the combination. I think that you should find out exactly which type of arthritis you have because if its RA, you might have to start on stronger medication to prevent joint damage.
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Regular Member

Date Joined Dec 2008
Total Posts : 224
   Posted 8/12/2009 8:45 AM (GMT -6)   
Sulfasalazine was much more commonly prescribed in the past for UC than at present. But a number of us still use it. In my case it has worked well.
Diagnosed with UC in 1990.
Current Meds: Sulfasalazine & Folic Acid.
Supplements: fish oil, flax oil, glucosamine, CoQ10, fiber, aloe vera juice, probiotics.
Other: Raw Milk for breakfast. Currently exploring a raw milk fast one day/week.

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