Positive Experiences with 6-MP

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expecting226
Regular Member


Date Joined Jul 2007
Total Posts : 402
   Posted 8/12/2009 9:56 AM (GMT -6)   
My GI is suggesting I move from Asacol to 6-MP.  I have done a ton (and I do mean A TON) of research and am concerned about the risks. 

Has anyone had any positive experiences with 6-MP?  Did it put you into a remission that lasted for a significant period of time?  How did you feel when you were taking it?  Side effects?

Thanks everyone!
Wearing many hats: Mother, Wife, Daughter, Professional, Sister, Friend
 
Current Medications:
- Asacol (4 pills, 3x per day)
- Rowasa (1 enema daily, as needed)
- Folic Acid (1 mg, 1x per day)
- Calcium (600 mg, 2x per day)
- Multi-Vitamin (1x per day)


suebear
Forum Moderator


Date Joined Feb 2006
Total Posts : 5698
   Posted 8/12/2009 10:35 AM (GMT -6)   
My experience with 6mp was positive in the sense that I did not experience side effects, but 6mp did not work for me after 1.5 years of hoping it would.

Sue
dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free


princesa
Veteran Member


Date Joined Aug 2007
Total Posts : 2204
   Posted 8/12/2009 12:36 PM (GMT -6)   
6mp didn't help me either. And it made my hair fall out and my toe nails grow weird, deep horizontal ridges. I had much better luck with sulfasalazine than asacol for an ASA med. I've also found a good quality probiotic, high doses of omega-3s and l-glutamine along with dietary changes worked much better for helping me achieve long-term remission.
Diagnosed with ulcerative colitis spring 1999. Have been in remission for years with only a few minor blips. Scope on 6/22 showed no inflammation at all.
 
Maintenance dose sulfasalazine. Probiotics, vitamin D, fiber supplement and fish oil caps. George's aloe vera juice and l-glutamine for gut healing. Mostly grain-free and dairy-free low carb diet.
 
 


AmyWaffle
Regular Member


Date Joined Jun 2009
Total Posts : 173
   Posted 8/12/2009 1:09 PM (GMT -6)   
6MP put me into remission for several years, with no noticeable side effects. It eventually stopped working, but that happens. I would give it a try!
UC since 1996 (age 20)
Mommy of 2 sweet little girls.
My life is one big flare.

Asacol, Azathioprine, Prednisone, Rowasa
First Remicade 6/22/09


Scarlet504
Regular Member


Date Joined Oct 2008
Total Posts : 192
   Posted 8/12/2009 2:15 PM (GMT -6)   
6MP also put me into remission from the third week that I took it - initially 75 mg a day. That would be 1 1/2 pills a day. I am now at 50 mg, because the side effects were too bad.
 
PROS: Puts me in remission; only 1 pill in the evening (I take 4 Asacol/day additionally as a cushion), makes me tired and therefore I sleep well, seems to keep me out of flares (haven't flared in 8 months, I use to flare every 3 months for at least 6 weeks).
 
CONS: Constantly tired, initial hair loss, initial headaches for days at times, initial nausea for weeks, body aches, no apetite, considerable weight loss, have to be monitored periodically by having blood work monthly (in the beginning it is weekly, then biweekly, then monthly - depends on the doc), can't drink alcohol when on 6MP (I don't drink, but if you do, you might want to consider it), sensitive gums and teeth, acne or at least several fat zits at the same time, dry skin, sometimes feeling shaky, sometimes dizziness. 6MP can considerably decrease the amount of the white and red blood cells, inhibits blood clotting and cause inflamation of the liver and pancreas and liver failure. Just to mention that.
 
Well, these are my PROS and CONS. I am willing to take all the cons just for the fact that I am not flaring. I can deal with the cons much better than with the constant loo trips, pain, bleeding, urgency, totally sick feeling ways of a flare and not being able to go somewhere or meet people.
 
But you have to decide for yourself.
 
Might sound very dark, but I don't worry about risks from 6MP anymore. I want to feel better NOW, I tried long enough just to stay only on "less harmless" meds like Asacol and enema and when i hit rock bottom, i took Pred and it didn't even work for me.
 
Please don't take it the wrong way and don't take it personally, i am not implying anything about the severity of your condition, but some people including me only realize how severe and torturing their condition is when they suffer for a long long time, because they are too scared to try something new, something controversial or something "risky".
I started taking 6MP out of total despair. I am scared of Remicade and Humira, but if the day ever comes that I have to give it a try, I certainly will first resist and throw a tantrum until I feel so poor and horrible that I am begging to try it out.
 
Best of luck and great that you are making an informed decision.
Scarlett, 38 yo., TX
Pancolitis since 3/1997
Meds
6 x Asacol a day
75 50 mg 6-MP
Align (probiotic)
Flintstones Complete Vitamins

AmyWaffle
Regular Member


Date Joined Jun 2009
Total Posts : 173
   Posted 8/12/2009 2:30 PM (GMT -6)   
Scarlet504 said...

CONS: (snip) can't drink alcohol when on 6MP


This has been discussed on here before, but I think alcohol in moderation when you are not flaring and are taking 6MP is generally considered fine.
UC since 1996 (age 20)
Mommy of 2 sweet little girls.
My life is one big flare.

Asacol, Azathioprine, Prednisone, Rowasa
First Remicade 6/22/09


Scarlet504
Regular Member


Date Joined Oct 2008
Total Posts : 192
   Posted 8/12/2009 2:35 PM (GMT -6)   
Consuming alcohol while on 6MP is not recommended as per information sheet that comes with the prescription from the pharmacy. Like I said, I don't drink and I can only imagine that 6MP in combination with alcohol can not be good for your liver. My doc always warns me that I should watch my Tylenol intake while on 6MP. And I swear, when I take more than 2 Tylenol a day on top of 6MP, i feel nauseous and sick.
Scarlett, 38 yo., TX
Pancolitis since 3/1997
Meds
6 x Asacol a day
75 50 mg 6-MP
Align (probiotic)
Flintstones Complete Vitamins

AmyWaffle
Regular Member


Date Joined Jun 2009
Total Posts : 173
   Posted 8/12/2009 3:19 PM (GMT -6)   
Scarlet504 said...
Consuming alcohol while on 6MP is not recommended as per information sheet that comes with the prescription from the pharmacy. Like I said, I don't drink and I can only imagine that 6MP in combination with alcohol can not be good for your liver. My doc always warns me that I should watch my Tylenol intake while on 6MP. And I swear, when I take more than 2 Tylenol a day on top of 6MP, i feel nauseous and sick.


6MP reacts with Tylenol?!

Post Edited By Moderator (Admin) : 8/13/2009 10:02:11 AM (GMT-6)


Scarlet504
Regular Member


Date Joined Oct 2008
Total Posts : 192
   Posted 8/12/2009 3:36 PM (GMT -6)   
Excuse me??? Don't twist my words. I said that I feel nauseated when I take Tylenol, because too much Tylenol can be damaging to the liver. Why do we go for liver tests while on 6MP when it has no effect on the liver?
 
Please be respectful and don't blow your BS whistle or whatever you call on me.  Just because you don't agree with me doesn't make it BS. Period.
Scarlett, 38 yo., TX
Pancolitis since 3/1997
Meds
6 x Asacol a day
75 50 mg 6-MP
Align (probiotic)
Flintstones Complete Vitamins

Blue220
Regular Member


Date Joined May 2008
Total Posts : 191
   Posted 8/13/2009 5:47 PM (GMT -6)   
I'm taking Imuran... Been on it since January. It started working 2 months after. I feel fine, generally speaking.

I'm tired as heck all the time, but I was like this before I took the Imuran. I also have bad headaches, but once again, I was like that before, and I think it's from the Lialda. I haven't switched anything because well, it works minus those things.

I didn't know you can't/shouldn't drink while taking Imuran/6MP. I do, but that's half a bloody mary once a week, and maybe half of another drink. Not anything large because any more than that makes me feel icky.
22 years old

Diagnosed with moderate/severe UC June 2007, I've had it since December 2006.

Haven't been on here in a while (finally graduated college).
Update as of 5/26/09 - Now taking Imuran 100mg/day.
2 Lialda/day.
Vitamins - Caltrate+D, iron, A, B12,
Flintstone Complete+iron, and aloe vera pills/juice.
At least I'm off the Entocort. =]


Shadam
Regular Member


Date Joined Jan 2009
Total Posts : 307
   Posted 8/13/2009 6:24 PM (GMT -6)   
I started taking 6mp a little over 3 months ago.  I started on 50mg then wen to 100mg but couldnt handle the side affects so I went back down to 50mg (currently still taking).  Before I started the 6mp I was the flaring very badly (10+ BM's a day).  I feel somewhat better now (3+ a day) but I did just get off of prednisone 2 weeks ago whcih I was on for close to 2 months...
Age: 25 / Male / Florida
Diagnosed: 11/08 / Pancolitis
Diagnosed with PSC: 3/9 --now taking Urso
Asacol - 2 x 3 day (waiting for results)
6MP - 50mg - 5/04/09 - 100mg - started 6/11/09 - back to 50mg 7/8/09
Mens Multi Vitamin - 1 a day
Vitamin A Deficient - 10,000mg a day
Calcium & Vitamin D3 - 1200mc of Calcium and 800iu of Vitamin D3  
Jaro - Dophilus Probiotic (3.4 Billion) - 1 a day
 
~~~Praying for a cure~~~~
 

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