Absolutely they can. I had horrible cramps in my feet and calves. Often it's because the pred depletes potassium in your body. Taking in extra potassium may relieve them - orange juice, bananas, soy and apricots are all high in potassium. I learned to always drink a glass of orange juice morning and evening when on pred.
Ulcerative colitis forum co-moderator
Moderate to severe left-sided UC diagnosed 2001.
Flared for 5 years, finally in remission with Remicade since March 2006.
Avascular necrosis in both shoulders is my "forever" gift from steroids.
Colazal, Remicade, Nature's Way Primadophilus Reuteri.
"My life is an ongoing medical adventure"