Apriso side effects - seems to be making things worse????

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kelli_C
Regular Member


Date Joined Jul 2009
Total Posts : 130
   Posted 8/18/2009 8:50 PM (GMT -6)   
so, i'm curious to see what you guys think about this...
 
I have been having a flare-up.  Went to the doc on monday and he did a small (unplanned, how fun!) exam, determined it wasn't hemmis, and gave me a rx for Apriso.  I'm only on the second day of apriso at this point.  The first day, I took the pills at 11 am with lunch, and starting around 3 pm, i started to get a sense of urgency that sent me home from work in such a hurry that imade the 25-minute trip home in about 14.  It was was major D.  After that trip to the bathroom, i was fine for the rest of the night and even had dinner.  No more BM's that night. 
 
Today i took the meds about 4 PM (few hours after lunch), and around 7:30 or so, started feeling urgency again.  Not as bad as yesterday, but still there.  So when i went to the bathroom, there was nothing there!!!!!  Just a few small bloody blobs (which i remember happening when i was first diagnosed back in 98, but hasn't happened during this latest flare). 
 
So the question is, does it sound like this medication is making the syptoms worse, or it this part of the healing process?  I am also starting a week of nightly mesalamine enemas tonight, too. 
 
Thanks!
Kelli
 
 
Ulcerative Colitis, dx in 1998 at age 18
Rowasa morning and night, Asacol 2x4
Allergic to Sulfasalzine
Now I take no meds or supplements (but some asacol on-hand if I feel a flare-up coming on)


fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 8/18/2009 8:59 PM (GMT -6)   
It's hard to say, honestly. Apriso DOES have a tiny amount of artificial sweetners in it, so if you're super-sensitive to them, that might be the problem. I can't remember how much, but I looked it up and compared the amount to what's in a diet soda, and it's way, way, way less. I can't drink diet soda, but I haven't had a problem with the Apriso. However, all of the 5ASA meds have diarrhea as a potential side effect.

As for the enemas, you need a LOT more than a week of them nightly. that's not nearly long enough!
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (currently tapering; 12.5 mg).


kelli_C
Regular Member


Date Joined Jul 2009
Total Posts : 130
   Posted 8/18/2009 9:06 PM (GMT -6)   
I actually have 14 days worth of enemas, i was wrong. 
Ulcerative Colitis, dx in 1998 at age 18
Rowasa morning and night, Asacol 2x4
Allergic to Sulfasalzine
Now I take no meds or supplements (but some asacol on-hand if I feel a flare-up coming on)


fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 8/18/2009 9:10 PM (GMT -6)   
That's really still not long enough! You'll need to use them every night until you get into remission and have been there for a few weeks. Then taper to every other night then to twice a week, and stay on the twice a week permanently. (that's what I did and continue to do, anyway) There is a lot of research showing that twice weekly mesalamine use keeps people in remission longer than those who don't use them.
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (currently tapering; 12.5 mg).


kelli_C
Regular Member


Date Joined Jul 2009
Total Posts : 130
   Posted 8/18/2009 9:21 PM (GMT -6)   
I'll mention it to my doc - I need to give him a call in a few more days to let him know how the apriso's working out, anyway. When i was first diagnosed, i had to take the enemas for months (in a dorm room with an unfamiliar roommate, no less!).

slightly off-topic momentary rant: The GENERIC enemas were $216 for 14 days. Luckily my insurance brought it down to $60, but i shudder to think of what the Name brand Rowasas cost! Thank God there's a generic now!!!
Ulcerative Colitis, dx in 1998 at age 18
Rowasa morning and night, Asacol 2x4
Allergic to Sulfasalzine
Now I take no meds or supplements (but some asacol on-hand if I feel a flare-up coming on)

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