I switched from Asacol to Apriso almost two months ago. The once-daily dosing most definitely rocks, and I think it'll be better for me in the long run as I had a lot of trouble remembering my noon dose, and sometimes my evening dose. I had an alarm set on my cell phone, but if it went off when I wasn't close to water, it didn't do me a lot of good! My GI said he thinks one of the biggest reasons people flare is b/c of not taking meds, whether that's by choice or by accidentally forgetting to take doses, so I was willing to rock the boat because of that.
I was taking 12 Asacol a day and now take 4 Apriso a day. I eventually want to taper down some, but my GI wants me to stay at the high dose for a long while b/c I was in such bad shape when I was diagnosed. I'm not sure if one can go higher than 4/day when flaring. Good question!
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (currently tapering; 12.5 mg).