Possible new treatment on the horizon.

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Hobo
Regular Member


Date Joined Jan 2006
Total Posts : 187
   Posted 8/20/2009 7:38 PM (GMT -6)   
Scientists make "sugar bug" drug for bowel disease

www.reuters.com/article/scienceNews/idUSTRE57J71I20090820

AMK77
Veteran Member


Date Joined Mar 2008
Total Posts : 678
   Posted 8/20/2009 7:41 PM (GMT -6)   
That's great!
32 yr old female
Mild Pancolitis
UC since 2000 - in remission for most of those 8 years med free.
Cannot tolerate mesalamine. Currently take probiotics and fish oil. Trying Applied Kinesiology & supplements.


uc_man
Regular Member


Date Joined Aug 2009
Total Posts : 36
   Posted 8/20/2009 7:43 PM (GMT -6)   
That is awesome! News like this makes me want to avoid surgery right now if I can - I have a feeling something new has to be coming that is successful for long term remission. Thanks for the link.
uc_man

25 yo
Diagnosed with Ulcerative Colitis in Spring 2003
Longest period of time without flareup: maybe half a year

Current Medications (as of 8/20/2009)
40 mg Prednisone (scheduled to taper down 10 mg weekly if symptoms improve)
50 mg Azathioprine (Imuran)
Remicade (IV - had two doses, third coming up in a week)
325 mg Ferrous Sulfate (Iron - twice daily until blood test shows not anemic)
10mg Loratadine (generic for Claritin)

Current Supplements (as of 8/20/2009)
Florastor probiotic (twice daily)
2x Os-Cal 500 + D
One a Day Men's Health Formula


UC_Hater
Regular Member


Date Joined Aug 2009
Total Posts : 45
   Posted 8/20/2009 7:49 PM (GMT -6)   
Bring it on!

Blue220
Regular Member


Date Joined May 2008
Total Posts : 191
   Posted 8/20/2009 8:23 PM (GMT -6)   
I hope!! I realllllllllllllllly do.
22 years old

Diagnosed with moderate/severe UC June 2007, I've had it since December 2006.

Haven't been on here in a while (finally graduated college).
Update as of 5/26/09 - Now taking Imuran 100mg/day.
2 Lialda/day.
Vitamins - Caltrate+D, iron, A, B12,
Flintstone Complete+iron, and aloe vera pills/juice.
At least I'm off the Entocort. =]


songlady
Veteran Member


Date Joined Aug 2009
Total Posts : 3646
   Posted 8/21/2009 6:08 AM (GMT -6)   
There are sooo many more drugs out there now than when I was first diagnosed, and such a better understanding of it all (bacteria, probiotics, etc) - I feel we're on the verge of a major breakthrough! This is exciting!
Diagnosed UP 1983, Azulphidine
Diagnosed UC 1986 Prednisone almost 2 years
Asacol - 16 pills a day
Metamucil - 2 doses a day
Cortenemas or Rowasa from time to time
VSL#3, Ultimate Flora Critical Care
Canasa as needed


chezzyman
Regular Member


Date Joined Sep 2008
Total Posts : 45
   Posted 8/21/2009 8:43 AM (GMT -6)   
Greaat, It makes me happy and hopeful
UC (Proctosigmoiditis) april 2008
Prednisone 25mg
Asacol 3x3
Asacol enema every second night
colon dophilus probiotics
 
-
flare up


mbx5
Regular Member


Date Joined Sep 2007
Total Posts : 365
   Posted 8/21/2009 9:00 AM (GMT -6)   
I like the time frame....finally something under 2 years....many new treatments and drugs are 10+ years away....if this happens in 18 months it would be huge. Sign me up for trials!!
Stats:35 yr old male. UC for 15 years.
location:North Western PA
DX: Left sided UC, most recent scope 5/20/09 UPMC Pittsburgh Presbeterian
Medications:No longer on Pred as of 6/15/09, 12x pills Asacol per day, 100mg Imuran per day, 1mg Atavan per day (anxiety) when needed, 20mg paxil per day, Super-omega fish oil pills - 1x per day, Flax oil pills - 1x am, 1x pm, Culturelle probiotics - 2x am, 1x pm, Vitamin B-12 injections monthly.
Surgeries: Recent Endonasal brain surgery to remove non-cancerous hormone producing tumor on pituitary gland (and I am still more afraid of my UC!!)

"I poop in the woods because I can"


fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 8/21/2009 9:19 AM (GMT -6)   
Interesting! But, typical for me, I want to know more!!! What does the human growth factor that is released do? How does it work?

And, from another standpoint, which I KNOW is off topic, I think it's so interesting how the general public is OK with genetically engineered bacteria which produce medicines, but the case isn't necessairly the same with genetcially engineered crops. I'm not pointing any fingers on here, I'm just making a general comment.
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (currently tapering; 12.5 mg).


fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 8/21/2009 9:26 AM (GMT -6)   
Ok, a quick google search revealed KGF-2 is a protein that stimulates mucosal healing...makes sense!
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (currently tapering; 12.5 mg).


Hellokitty
Veteran Member


Date Joined Mar 2009
Total Posts : 765
   Posted 8/21/2009 9:39 AM (GMT -6)   
I didn't really understand how this is supose to work. we are still adding bad bacteria into our bodies all the time. how can this be a permant thing. I think there will be a break through too. I am hopeful.
Female 32 years old
 
Diganosed ulcerative colitis November 2007
Present medication-  500mg pentasa,  250 mg  asacol (every evening)
Diet- Back on the raw foods.
 
Other medical problems- Born with asthma- no medication taken for this.
dyslexia- found out that many people with learning difficulties also have food sensitivity
 

fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 8/21/2009 9:51 AM (GMT -6)   
Kitty, this bacteria is NOT a harmful one. And remeber, we have a LOT of good bacteria in our bodies as well...we wouldn't be able to digest foods without them, and that's what probiotics are!

This bacteria has been genetically modified so that it produces a human protein called KGF-2. KGF-2 naturally occurs in our bodies and is involved in stimulating mucosal healing (and therefore the mucosal lining of our colons which is inflamed). This bacteria has also been designed to not produce the KGF-2 until the person also ingests xylan, I'm guessing so that there is a measure of control on where the KGF-2 is produced and released.
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (currently tapering; 12.5 mg).


cra43
Regular Member


Date Joined May 2008
Total Posts : 172
   Posted 8/21/2009 10:19 AM (GMT -6)   
Hey , what if you're on remicade,,,??? would you quit it to do this??? Still a lot of questions,
but if it works it would be great.

fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 8/21/2009 10:21 AM (GMT -6)   
I personally wouldn't if the remicade is working well, since this is still experimental and doesn't seem to have been trialed in humans yet.
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (currently tapering; 12.5 mg).


subdued
Veteran Member


Date Joined Dec 2008
Total Posts : 3231
   Posted 8/21/2009 12:52 PM (GMT -6)   
The idea of putting bacteria into our body is the same idea behind fecal transplantation. The high success rate of using fecal transplantation in treating C-diff is becoming well-known. I'm not surprised scientists are getting involved in creating something that will work in pill-form. There is great promise that a "drug" such as this will be able to help at least some people with Chron's and Colitis. I'm still glad I did fecal transplantation though. Not only does it put more strains of bacteria back into the colon, but I don't have to take medications while waiting for this new "drug" to be developed and tested.


Joy - 47 yrs and counting; Dx Colitis Dec 06 (also had IBS); Currently in remission

Figuring out how to reduce a flare or get into remission is a trial and error experience. Don't expect your GI to have all the answers. He was trained in making diagnoses, prescribing medications, and surgically removing the colon. He was not trained in alternative treatments. That's why they are called alternative treatments.

What works for me: Fecal transplantation, Probiotics, Anti-inflammatory foods, No HFCS, No foods high in fructose, No artificial sweeteners, No pro-inflammatory foods when flaring, Vitamins, Lexapro (for stress).

Post Edited (subdued) : 8/21/2009 12:56:27 PM (GMT-6)


fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 8/21/2009 12:55 PM (GMT -6)   
I just want to reiterate that the bacteria ITSELF isn't doing anything. This bacteria has been genetically engineered to produce a human protien that is involved in mucosal healing. So it's not anything like probiotics or fecal transplantation.
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (currently tapering; 12.5 mg).


NiRo
Regular Member


Date Joined Aug 2009
Total Posts : 198
   Posted 8/21/2009 12:58 PM (GMT -6)   
Exactly right - the bacteria IS the pill in this case in a weird soft of way. Meaning it's what helps to deliver the KGF-2. The sugar is what helps trigger when the bacteria becomes 'active' and releases KGF-2.
Lialda 4x a day (2x in the morning, 2x at night)
Rowasa Enema 1x at night
Align (Probiotic) 1x a day
Fish Oil 4x a day
Multi-Vitamins (includes B-12, Vitamin D, Vitamin C) 1x a day
Diagnosed with Pancolitis (Moderate in 4/5th of the colon, Mild in 1/5th) in July 2009


subdued
Veteran Member


Date Joined Dec 2008
Total Posts : 3231
   Posted 8/21/2009 12:59 PM (GMT -6)   
fruitgirl said...
I just want to reiterate that the bacteria ITSELF isn't doing anything. This bacteria has been genetically engineered to produce a human protien that is involved in mucosal healing. So it's not anything like probiotics or fecal transplantation.

Hmmm... Bacteria plays a role. It might be more specific in this case, that of producing a human protein that is involved in mucosal healing, but it is playing a role nevertheless.


Joy - 47 yrs and counting; Dx Colitis Dec 06 (also had IBS); Currently in remission

Figuring out how to reduce a flare or get into remission is a trial and error experience. Don't expect your GI to have all the answers. He was trained in making diagnoses, prescribing medications, and surgically removing the colon. He was not trained in alternative treatments. That's why they are called alternative treatments.

What works for me: Fecal transplantation, Probiotics, Anti-inflammatory foods, No HFCS, No foods high in fructose, No artificial sweeteners, No pro-inflammatory foods when flaring, Vitamins, Lexapro (for stress).

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