I have been on imuran for four years. After I came off of prednisone in 2005 I went on 150 mg of imuran and have been symptom free until April 2009. I found in the first weeks I had joint pain, and blood shot eyes, but after that it was smooth sailing. I never once threw up as a side effect.
I am currently in a flare, which has been caused by losing a job and my father is ill. However I have read that imuran stops working after 4 years.
If I could live symptom free on imuran my entire life I would in a second. My doctor has now increased my imuran to 175 mg and I take 500 mg of salofalk orally and in enema form (not fun).
Hope this helps