I'm on Apriso, which is quite similar to Lialda in that's it's a once-daily mesalamine drug. I take 4 pills, all in the morning with breakfast. I'm sure you could take part in the morning and part at night...the main reason for the one-daily dosing is convenience, because many people (like me!) have problems remembering multiple doses during the day, and therefore end up not taking as much medicine as they should, which can lead to relapse.
I eventually want to lower my Apriso dose (mainly so I can increase it if I start to flare, if that makes sense), but since I was so, so, so sick, my doctor wants me to stay at this dose until I've been in remission for a while.
Do you think there's any possibility that your nausea is related to your UC and not to the meds? Or that maybe you're a little anxious about being on Lialda?
Also, if you can tolerate them, definitely get on a mesalamine enema!
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Diagnosed with pancolitis on 1/30/09
Currently meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, and Zoloft (currently tapering; 12.5 mg).