Posted 9/27/2009 11:41 PM (GMT -6)
I'm familiar with it as far as living it, this is basically what my problem is (which I refer to as having urgency issues). I know that IBS can cause it...
Rectal hypersensitivity induced by repetitive rectal distention (RRD) is reported to be a response specific to patients with irritable bowel syndrome (IBS), and is not observed in healthy controls. We evaluated the rectal pain threshold (PT) and determined whether intravenous corticotropin-releasing factor (CRF) induces rectal hypersensitivity after RRD in healthy humans, that is, whether it mimics the response observed in IBS patients.
A double-blind placebo-controlled study design (CRF or vehicle) was used. In the first experiment, PT (mmHg) induced by ramp distention was measured by a barostat. Then CRF (100 µg, n = 5) or vehicle (n = 6) was injected intravenously (iv) followed by RRD, consisting of phasic distentions with sensory tracking, which lasted until the subjects had complained of pain six times. After RRD, PT was measured again. In another experiment, PT was measured, and then CRF (n = 5) or vehicle (n = 5) was injected iv. After 45 min, ramp distention was again induced to determine PT.
In the placebo group, PT was not modified by RRD (before RRD, 33.0 ± 6.8; after RRD, 33.4 ± 4.5), while it was significantly reduced in the CRF-treated group (before RRD, 32.9 ± 9.0; after RRD, 26.1 ± 7.9, P < 0.05). On the other hand, CRF or vehicle without RRD did not alter PT (before iv-CRF, 35.2 ± 4.2; after iv-CRF, 35.3 ± 4.9; before iv-vehicle, 34.5 ± 7; after iv-vehicle, 35.5 ± 6.8).
These results indicate that CRF modifies rectal sensation in healthy humans and mimics an IBS-specific visceral response, suggesting the possible contribution of CRF to the pathogenesis of IBS.
And I have been DX with having IBS as well as crohn's colitis (CD affecting the colon) and I have to say that at the beginning when I got sick, I probably would have pooped myself had I not been able to get to a toilet in time BUT I was able to hold it in longer then, then it seems that around the time my GI suspected I also have IBS is when it was getting harder to hold it (and much shorter time span holding it in) so I don't know if it's also related to IBD only but like I said above, since being DX with IBS as well I find it much harder to hold it in (impossible actually) than I did when I first got sick with crohn's and I was flaring severely then too. Plus, I don't even have D so I'm talking formed stools and I cannot hold them back (which shocked the heck out of me when I discovered this).