I switched from Asacol to Apriso because I was noticing medication in my stool. Apriso starts dissolving at a lower pH than Asacol, and people with UC are thought to have more acidic guts. I'd definitely talk to your doctor...Are you in the UK? I'm not familiar with what all forms of mesalamine are available there.
Co-Moderator, UC Forum
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son
Diagnosed with pancolitis on 1/30/09
Meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, multivitamin. Used prednisone (starting dose 40 mg) to get into remission.