I handled it with Xanax and it went well. I LOVED the energy it gave me and that my joints felt so good because I have arthritis! I only side effects I had was moonface (not fond of that) and wanting to eat everything in sight (and I am already obese). I loved the long fingernails and smooth skin. I wish someone would invent a prednisone-like medication to do all that AND stop the bleeding. Worked great for me. Took it 5.5 months and tapered really slowly - not the fun part!