Hi Aroz and welcome to HealingWell. Can I ask how extensive your daughter's UC is (left-sided, pancolitis, etc?). I'm sorry to hear she was diagnosed, but I'm glad that you found us. Send her over here, too, if she needs some support!
I'm on Apriso, but am only taking four 0.375 per day, so a total of 1.5g of mesalamine (the active ingredient). Most other mesalamine drugs (Asacol and Lialda, for example), have a maximum daily dose of 4.8g of mesalamine per day. So even at eight Apriso, that's still only 3.0g.
The reason that Apriso has such a lower daily dose is because it supposedly delivers the mesalamine in a much more effecient manner. However, Apriso is a fairly new drug, so it kind of remains to be seen whether or not this is really the case. I can say that I am maintaining a very solid remission on it, though. Apriso isn't actually indicated for inducing remission (to my knowledge, anyway), just maintaining remission. So that's perhaps why your daughter's GI has her on eight per day.
At any rate, I don't think it will be damaging, but do check with her doctor. Also know that the colon isn't very effecient at absorbing mesalamine, so very little drug is actually entering her bloodstream.
I highly suggest that she asks her doctor about mesalamine suspension enemas. They help just about everyone who trys them. Studies show that people who use them every night in conjuction with oral meds achieve remission more quickly than those who only use oral meds, and that people who use them twice weekly in conjuction with oral meds stay in remission for longer than those who only use oral meds. I also encourage her to start taking a good, high-quality probiotic.
Co-Moderator, UC Forum
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son
Diagnosed with pancolitis on 1/30/09
Meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, multivitamin. Used prednisone (starting dose 40 mg) to get into remission.