Please keep in mind that this post is just my opinion on this subject. I personally have been where your wife is. I have had blood stools for months making my life almost impossible and very difficult on those around me. I choose to try the meds first in a systematic and chronological order which is almost the way UC is treated by most GIs and colorectal surgeons. Of course there are exceptions but most will start with prednisone, with mesalamine meds. I was treated the same but it didn't work for me. I eventually had to go to an immunosuppresant which is common for many UCer's. I have been put on Imuran which is working very well for me, no blood, no urgency, have gotten my life back. If this fails, then comes the class of biologics like Remicade or Humira. Most colorectal surgeons won't even entertain the idea of surgery unless one goes through the various meds first. When I was having problems a respected colorectal surgeon said look you have UC but you have only taken prednison and asacol, you have just scratched the surface. You need to try the other meds first. Once those fail surgery is always an option.
Let me also say that there are many people here in this forum that don't want to take any meds, such as immunosuppresants or biologics but I am not one of them. I will first try those meds and if those work I will gladly surgically remove my colon. So, my only advice is to slow down and try the other medications first but this is a personal and family decision. In conclusion, don't despair there are options for you and your wife, you just have to give it more time and be aggresive in treating your UC.