I really don't get the concern. I am a commercial pilot and the pressurization is just to make the air pressure more like it is on the earths surface since we would all pass out at cruising altitude pressure without it. It is not greater pressure than we are already used to. Probably slightly less.
What I would be concerned about is the seat belt sign being on, remain seated etc during turbulence, take-off and landing. I would inform the stewardesses at the start of the flight you have UC and basically it means there are times you need to go immediately and cannot hold it.
I would not want to be walking around in turbulence and hit my head on the ceiling and die like the woman did on the flight to Japan on UAL so I would 'FAST' for 24 hours before the flight so I don't need to go - period.
I saw that performance artist guy, cannot recall the name but he was saying before he spent a week underwater he fasted for like 72 hours or something so that he would not have to go at all.
yeah I don't have any issues in relation to pressure.
I've never been on a flight that's 10 hours long... It's really nerve racking. I've been pretty lucky with understanding stewardess's and crew, but it does get difficult. If I see that the light is on, but they're walking around or anyone else gets up.. I will to if I need to go.
I don't really see hitting your head and dying as a common occurrence and I'm pretty sure that was a rare case, but that would definitely suck.