I use as needed according to my doctor's instructions. My experience is good. I have IBS and have taken Imodium for years in small doses - along with pepto bismal for nausea.
I know everyone is affected differently but my experience is that I have not had any problems - when I take 1/2 pills a couple times a day like on vacation I do come home a little constipated but when back to normal eating I am fine.
I never take more than one at a time - about 4 hours apart.
Senior - diagnosed with proctosigmoiditis - 6/2008 Cannot tolerate mesalamines including rectal meds, etc.
Prednisone for about 5 months - tried 6 MP with no help.
No prescriptions now except for Cortifoam and anusol about once a week. Now treating only with Imodium and Pepto Bismal and below....
Probiotic Align, Prilosec for GERD, Gas-X, vitamins, Calcium/D
Tylenol for knees and arthritis.