Flare while on Apriso

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Regular Member

Date Joined Apr 2009
Total Posts : 30
   Posted 9/12/2010 5:32 AM (GMT -7)   
Has anyone had a flare while on Apriso? I am having a small flare, some blood and going to bathroom 3-4 times a day. It seems to be related to diet - coffee and alcohol, so I really need to cut those out. If you had a flare on apriso, did they give you additional medicine to take?

Regular Member

Date Joined May 2010
Total Posts : 126
   Posted 9/12/2010 8:07 AM (GMT -7)   
I take 4 pills a day and that was never enough to get rid of my flare. I finally used Rowasa, rectal meds to get rid of it. You should ask your doctor for it. Some people on here take 8 pills when flaring, just thought.
UC in Sigmoid April 2010
Rowasa nightly
vsl #3 DS 
SCD since June 2010

Veteran Member

Date Joined Dec 2006
Total Posts : 914
   Posted 9/12/2010 8:08 AM (GMT -7)   
How many Apriso tabs are you taking? It was common for my doc to bump up the oral mesalamine at the first sign of a flare. If that wasn't enough, my doc would get me to do a mesalamine enema overnight. I believe I headed off many flares doing that. Do you have left sided or pancolitis BTW?
DX Pancolitis 2003. Subsequent flares limited to left side
Flare every 2-3 years.
Apriso 2 x 4 tabs daily, Mesalamine enema 1 X daily.
Probiotics: Primal defense and VSL#3DS. Fiber: Psyllium and "super seed".
Allergic to Imuran

Currently mild flare last 6 months. Limited to Rectum and lower sigmoid. No diarrhea.
Switched from Cortifoam to Colocort @night
Prednisone 2.5 mg OFF!!!

Regular Member

Date Joined Aug 2010
Total Posts : 22
   Posted 9/12/2010 1:28 PM (GMT -7)   
I am on 8 Apriso capsules while in flare.  This is also new medicine for me however I believe the Dr. will reduce me to the maintenance dosage of 4 capsules once I can get past this flare.
Just wanted you to know.  I've read several postings of individuals who took 8 Apriso capsules while flaring and 4 for remission.
DX, UC 9/2001 during my first pregnancy
CDifficile, pseudomembraneous colitis, 3/2005 after antibiotic
Apriso, 8 per day to get me out of a flare (is it going to work?)
Canasa, once per day
Hydrocortisone Enemas, every night during flare
Flora Q2 Probiotic, Fish Oil, Metamucil (current 4 capsules per day)

Prior Med's that quick working or never worked
Asacol, Rowasa, Pentasa, Colazal

Regular Member

Date Joined Apr 2009
Total Posts : 30
   Posted 9/12/2010 6:58 PM (GMT -7)   
I am only taking 4 apriso pills once a day so I thinl I'll talk to my doctor about increasing to 8 and adding rowasa enemas (rowasa is what got me under control when I was first diagnosed). I have left sided colitis. Has anyone found modifying diet helps? I'd like to aviod steriods if possible!!

Thanks so much!!
31 year old female, diagnosed w/ left sided UC on 4/6/09
18 month old son - diagnosed 4 months after he was born
1 Rowasa enema nightly
Liada 4 pills a day
Apriso 4 pills a day
Also taking Synthroid and Lexapro
Live in Ohio

Forum Moderator

Date Joined Dec 2008
Total Posts : 15256
   Posted 9/12/2010 7:07 PM (GMT -7)   
Goodluck. I flared while on Asacol and nothing would help stop it except prednisone. I am still struggling to become stable. You sound like you're in much better shape than I was. Enemas will probably help get things back under control. You could try the cortfoam enemas if Rowasa doesn't help.
March 2007: Diagnosed with Mild Proctitis - Canasa as needed.
August 2008 - December 2008: FLARE & Anemic - Started Asacol!!
January 2009 - December 2009: REMISSION!! Asacol (9) + Canasa 2x Daily
December 2009 - January 2010: FLARE!! Asacol + Prednisone + Canasa
February 2010 - April 2010: Colazal + Prednisone + Canasa
May 2010 - June 2010: Lialda + Cort Enema + Prednisone : Colonoscopy: Mild / Moderate Active Pancolitis
CURRENT: DOING OK! Prednisone, 6mp, klonopin, Canasa + Vitamin D

Durango Kid
Regular Member

Date Joined Jul 2009
Total Posts : 330
   Posted 9/12/2010 10:55 PM (GMT -7)   
Brinda said...
 Has anyone found modifying diet helps?
You'll find a bizillion posts on this board concerning diet.  I personally don't believe diet will get me into or out of a flare.  Some foods will irritate me however if I'm in a flare.....

U.C. (Proctosigmoiditis) DX 2004 after quiting smoking
Flaring over a year now. Getting closer to remission...
CURRENT MEDS: UC=Asacol 400mg 3x3 daily; Finally Off the evil Pred; Azathioprine 100mg (Discontinued due to elevated liver enzymes); Hydrocortisone enema as needed; Imodium as needed; Probiotic 12 billion cfu; Psillium tablets; Turmeric; Fish oil; Multi-vitamin
Hypertension=Cozzar Cholesterol=Welchol; Zetia

Regular Member

Date Joined Jul 2010
Total Posts : 28
   Posted 9/13/2010 5:17 AM (GMT -7)   
I had a small flare, non-solid bowel movements, very sudden, and about 4 times a day, but no blood nor pain, nor nausea.
My doctor put me on enemas, solved all my problems, and I am off of them now.
Even though Apriso is a slow release capsule, which helps a lot of people, oral mesalamines still have one weakness, and that is not reaching the whole colon, which is why in most cases, with a small flare, rectal mesalamines are needed.
Current Medications:
Apriso - (4) .375gm once a day, Advair Diskus - 100/50 twice a day, Azathiroprine - 75mg once a day, Allegra - 60mg twice a day, Nexium - 40mg once a day, Vitamin D - 50,000 IU once a day
Past Medications:
Colozal, Iron, Lialda, Prednisone

Elite Member

Date Joined May 2003
Total Posts : 29798
   Posted 9/13/2010 10:46 AM (GMT -7)   
yep, stress the rectal meds....5ASA mesalamine would be the best place to start.

You won't avoid a flare with only Apriso considering UC flares start at the rectum.

*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Ranitidine; Effexor XR 37.5mg (depression), Pulmicort/Airomir (asthma)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care+Primadophilus Reuteri capsules @ bedtime
~Metamucil capsules 6 twice daily with meals; Vitamin D 2000 IU
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!

Veteran Member

Date Joined Mar 2008
Total Posts : 2855
   Posted 9/13/2010 12:20 PM (GMT -7)   
These drugs won't completely prevent flares.
I always had to up the dose and add prednisone when I flared. I have no idea how I would have been without asacol, I was afraid to try.
I have stopped asacol now that I am on Remicade, however.
49 year old female attorney, diagnosed UC/pancolitis 1985.
Asacol for 20+ years with Prednisone & Rowasa for flares (But nothing since Remicade).
Food sensitivity test by Naturopath showed wheat/gluten, other intolerances, helped some. Remicade started April 2009 (Humira denied) and doing great~ learning what normal is~ wow
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