Mutaflor versus VSL3

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Veteran Member

Date Joined May 2007
Total Posts : 768
   Posted 10/7/2010 1:16 PM (GMT -7)   
I tried VSL3 for a month (2 sachets a day) with no positive results. I was told that I would have (probably) been better taking 3 per day.

My GI said that Mutaflor is more affordable and has had decent reviews.

I've checked out the Mutaflor site but it's almost impossible to compare the two as far as ingredients are concerned. They seem to be quite different animals. I guess the good thing is that it's about a third the cost of VSL3.

Anyhoo, I was wondering if anybody here has tried Mutaflor, and/or tried both and compared results if any?

Regular Member

Date Joined May 2010
Total Posts : 312
   Posted 10/7/2010 4:00 PM (GMT -7)   
Check out - tons of studies there. Probiots seem to maybe work...

CONCLUSIONS: The probiotic drug E coli Nissle 1917 shows efficacy and safety in maintaining remission equivalent to the gold standard mesalazine in patients with ulcerative colitis. The effectiveness of probiotic treatment further underlines the pathogenetic significance of the enteric flora.

VSL#3 (VSL#3) is a high-concentration probiotic preparation of eight live freeze-dried bacterial species that are normal components of the human gastrointestinal microflora, including four strains of lactobacilli (Lactobacillus casei, L. plantarum, L. acidophilus, and L. delbrueckii subsp. bulgaricus), three strains of bifidobacteria (Bifidobacterium longum, B. breve, and B. infantis), and Streptococcus salivarius subsp. thermophilus. Data from noncomparative trials suggest that VSL#3 has clinical potential in the treatment of active mild to moderate ulcerative colitis and as maintenance therapy for patients with ulcerative colitis in remission. In addition, a randomized, open-label, multicenter trial showed that VSL#3 in combination with low-dose balsalazide (a prodrug of mesalazine [mesalamine; 5-aminosalicylic acid]) was more effective than standard doses of basalazide or mesalazine monotherapy in the treatment of acute mild to moderate ulcerative colitis. Randomized, double-blind, placebo-controlled studies have shown VSL#3 is effective in preventing the onset of acute pouchitis in patients with newly formed surgical pouches, and in maintaining remission following antibacterial treatment of acute pouchitis in patients with a history of refractory or recurrent pouchitis. Treatment guidelines from the US and the UK include VSL#3 as a therapeutic option for the prevention of pouchitis relapse in patients with chronic pouchitis. In general, VSL#3 was well tolerated in clinical trials. Large, well designed, controlled confirmatory clinical trials will further determine the place of VSL#3 in the treatment of ulcerative colitis.
40 g of prednisone. 30 on Friday, then 20, 15, 10, 5,4,3,2,1
6 x 800 asacol -wanting to start VSL#3 at night. Should I?
Hemoglobin dropped from 9.3 to 8.7 despite no more blood loss last 2 weeks due to Prednisone. Red blood cell production is excellent. Odd.
Chinese lady says I have worms. :)
See specialist on the 28th, will ask for Salofalk.

Veteran Member

Date Joined Mar 2010
Total Posts : 1180
   Posted 10/7/2010 5:11 PM (GMT -7)   
I started on mutaflor last spring. I got lots of farting gas the first week or so. It definitely seemed to help. I took two pills a day for about a month while eating homemade yogurt. The yogurt definitely seemed to help also.

Then I started making the yogurt with VSL# 3 at that time and continued on two pills. No dramatic change but seemed to help. I reduced the mutaflor after 2 months down to one pill then quit after 4 months total.

If I had more money I would still be taking it. I kind of didn't really trust the company..just some little things. I still eat a large helping of VSL#3 yogurt every day. All the bacteria in VSL#3 is lactic acid ie yogurt strains. Some if the literature like the SCD book claim fresh yogurt gives you a massive dose.. much more than the pills or packets.

I started S. Boulardi(yeast) somewhere in there. Never noticed that it helped. Cheap so I still take it.

I ran into a study from Europe(?) on colazal(which I take) plus probiotic( VSL#3?) that showed positive effects on diverticulous(which I have) and showed that you can take less colazal with VSL#3 and get better results than more colazal alone.

No science here but I kind of think that you get a bigger effect at first and then maybe less later will probiotics. I would still take mutaflor if it was less expensive. $1080 a year is kind of a lot.

Veteran Member

Date Joined Oct 2009
Total Posts : 2818
   Posted 10/7/2010 5:50 PM (GMT -7)   
I tried both with no results. Mutaflor gave me gas for the first six weeks. With gas comes a little diarrhea so I had to stop. I switched to Align and have no idea if that's doing anything either. The price is better for Mutaflor because one packet is the lowest dosage for UC, two packets is more recommended, but who can afford that?

Veteran Member

Date Joined May 2007
Total Posts : 768
   Posted 10/8/2010 12:56 PM (GMT -7)   
Thanks guys, methinks I'll try the Mutaflor as it's only $80cdn for a months supply.

If it doesn't do the business then I'll try the VSL at the higher dose. It's got a month to do something positive.

Baconeggsyum, I appreciate the detailed info but if I'm honest, to me it's reads like a load of gobbledygook! I guess I'm just plain thick as a brick at chemistry! :)

Regular Member

Date Joined Oct 2013
Total Posts : 27
   Posted 10/24/2013 11:03 AM (GMT -7)   
Has anyone here tried "Renew Life Critical Care 50 billion" ? They also sell a stronger version.
It is enteric coated and contains 50 billion cultures with 10 different strains per capsule.
I was having some slight bleeding and after a few days of using Renew Life the bleeding went away & my bowel movements got better

Veteran Member

Date Joined Aug 2012
Total Posts : 9088
   Posted 10/24/2013 11:24 AM (GMT -7)   
I tried the 80 billion and it immediately made me much worse. They lie about the enteric coating. It is not enteric coated. You can tell by just looking at it. It is nothing but a normal capsule.
Lialda 1 pillX3; VSL#3 112.5mgs 1 pillX2; Prescrip Assist Probiotic 1 pill X 2;Vitamin D3 5000 ius 1 pillX2;Levsin;DAO;Folic acid. Pred taper.

Discontinued: Robinul; Natural - peppermint oil, Inflaguard (Boswellia), Pepto Bismol, Omega 3 fish oil, Imodium, Beano, Lactaid;Zymactive, Renew Life Probiotic 80 billion, Florastor, DGL, Monolaurin, slippery elm;black cherry concentrate;CCHerbal

Regular Member

Date Joined Oct 2013
Total Posts : 27
   Posted 10/24/2013 12:53 PM (GMT -7)   
They supposedly offer a 60 day money back guarantee. Maybe you should ask for a refund.
Do you watch what you eat or drink while taking probiotics ?

Not sure if this might apply to your experiences with probiotics.
This link might explain what might have happened in your case.
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