So how far have you dropped and how long ago did you do it?
It honestly sounds like you've gone too low, and your UC is going to need more than that. FWIW, I don't think it's such a big deal to be on higher doses of mesalamine...look at songlady, for instance. I also have no intentions of changing my meds as my doc says what I'm doing is perfectly ok for long, long, long term. Yeah, Apriso is a lower amount of mesalamine, but it's (supposedly) formulated to make the mesalamine more available. So maybe my body is experiencing the same amount of mesalamine as if I were on 12 Asacol/day.
I say up the meds back to where you were when you were doing ok and just stay there.
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son
Diagnosed with pancolitis on 1/30/09
Meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, multivitamin. Used prednisone (starting dose 40 mg) to get into remission.