Lialda's active ingredient is Mesalamine, which is also in Asacol and Apriso. Asacol was the first mesalamine drug developed; Apriso and Lialda are "newcomers." Bascially, the only difference in them is their delivery system (how they break down in your colon). I guess call your doc and mention that you've never taken Aspirin. My guess is they'll probably have you go ahead and take it, since you have no idea if you have an Aspirin allergy. FWIW, I can't take Aspirin b/c it tears up my gut (gives me diarrhea), but I have no problems with mesalamine drugs. However, the diarrhea I get is a sensitivity and not a true allergy.
Mesalamine really helped/helps me a lot. I just about
got into remission with Asacol and mesalamine enemas, but got a tummy bug from my son that threw me back into the flare. So I ended up using a relatively quick course of prednisone to get into remission. I've since switched to Apriso, and it and a mesalamine enema twice weekly has kept me in remission.
You may want to consider asking your doctor about
enemas. They'll do a lot to heal the lower portion of your colon that the Lialda might not reach. Studies show that patients who use them in addition to oral meds fair better than those who only use oral meds. It's not really as bad as you might think to use them, either.
Status: Remission since May 2009!
Symptoms began in November 2008, ~4 weeks after giving birth to my son
Diagnosed with pancolitis on 1/30/09
Meds: Apriso (4 0.375g pills ONCE!! daily), mesalamine enema twice weekly, Natural Factors Ultimate probiotic 12/12 Formula, multivitamin. Used prednisone (starting dose 40 mg) to get into remission.