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LK
New Member


Date Joined Nov 2010
Total Posts : 7
   Posted 11/19/2010 6:51 AM (GMT -7)   
So I've been in a flare of my UC since August. Just bleeding and some mucus. about 3 weeks ago it started getting better, following use of probiotics. Dramatic reduction in bleeding, no mucus. Then last Thursday I began having diarrhea - I thought it was a new UC symptom. But then my husband and kid got it too over the weekend, so then I figured it was a bug. They had it for about 48 hours. Up through yesterday, I've had it about a week (none yet today, doing somewhat better.) Wednesday morning, about 2 am, I went to the ER with severe abdominal pain and was diagnosed with acute pancreatitis. The most common causes evidently are alcoholism and gallstones. I don't drink and I had my gallbladder out a few years ago.

I googled pancreatitis and UC and found some sites mentioning a rare link between these 2 illnesses. I found a few more links saying that Asacol (which I am taking for the UC) has been known to cause pancreatitis.

The ER doctor could not explain why I have pancreatitis and sent me home with instructions to follow up with my GI. Can't see the GI until Monday. Getting alot of conflicting information in general, though, so wanted to check in with you all.

Does anyone have pancreatitis? Know of a link to UC or to mesalamine? Have advice?

Thank you!
Laura

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 3008
   Posted 11/19/2010 7:20 AM (GMT -7)   
Drinking soda has been associated with pancreati*** or perhaps cancer of the pancreas and you dont want to mess with it, it has the worst survival rate if you develop cancer of the pancreas.

suebear
Forum Moderator


Date Joined Feb 2006
Total Posts : 5698
   Posted 11/19/2010 7:42 AM (GMT -7)   
I didn't realize that pancreatitis leads to pancreatic cancer?

I think you have a higher risk of getting pancreatitis if on 6MP. But I know many people who have had it that don't have IBD and aren't on medications.

Sue

Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23549
   Posted 11/19/2010 8:32 AM (GMT -7)   
Chronic long term inflammation of the pancreas can increase the risk of pancreatic cancer much like chronic long term inflammation of the colon can increase the risk of colon cancer. But usually the pancreas will tell you if it's not right much like it did for Laura. I have not heard of 5-ASA's can cause pancreatitis but it doesn't mean it can't happen. I know that 5-ASA's can affect the kidneys. When you find out from your doctor, please let us know ok Laura?
SHERRY
Moderator-Allergies/Asthma and Alzheimer's, Co-moderator-UC
~Left sided Uc-'92**Unable to tolerate ALL mesalamines**
Colazal(9 daily)/6mp(25mgs), Allopurinol (100mgs)/Bentyl-Prilosec~allergies-Singulair/Zyrtec~Reynauds Syndrome~OA-Tylonel Arthritis~Scoliosis~Sacroilitis~Dry eye-Restasis/GAD - Klonopin (.25mgs)

Zippy123
Veteran Member


Date Joined Feb 2009
Total Posts : 735
   Posted 11/19/2010 9:36 AM (GMT -7)   
My one older brother had multiple pancreas attacks, no known cause or reason, at first they thought diet would help but it didn't make any real difference. He wasn't on any drugs that I know of. They even removed his gall bladder thinking it would help, but that wasn't it either.

quincy
Elite Member


Date Joined May 2003
Total Posts : 29860
   Posted 11/19/2010 10:56 AM (GMT -7)   
My sister had her gallbladder out but still produced stones without it...resulting in chronic pancreatitis. She did have many ERCPs as well...could be one connection as well.

You definitely need to get to the GI asap, have the pertinent testing such as an MRCP or whatever else can detect what's going on before having an ERCP...unless you have a blockage, you will probably need one.

What meds are you on Laura and where is your UC located?

q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Ranitidine; Effexor XR 37.5mg (depression), Pulmicort/Airomir (asthma)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care+Primadophilus Reuteri capsules @ bedtime
~Metamucil capsules 6 twice daily with meals; Vitamin D 4000 IU
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!

suenew61
Regular Member


Date Joined Feb 2010
Total Posts : 103
   Posted 11/19/2010 11:55 AM (GMT -7)   
Mesalazine can cause pancreatitis - I think you will find it as a rare side effect on the drug package insert, and it did cause pancreatitis in my daughter.
She had been on Pentasa but then swapped onto Mesevant XL when the symptoms started to show. As soon as she came off it the pancreatitis resolved, but when she was re-challenged the pain returned and her amylase began to rise again.
Acute drug induced pancreatitis has no link with pancreatic cancer, it is ongoing chronic pancreatitis that can be associated with it.
Do you know how high your amylase reached? I would get in contact with your GI to discuss, and if the pain returns don't delay and get checked out in ER.
Sue
Daughter(17) diagnosed severe pancolitis Nov 2009
Off all mesalazine following acute pancreatitis
Currently in remission!!
6MP(25mg/day) SCD, Vitamin D, Lecithin(phosphatidylcholine), VSL3 and Mutaflor

LK
New Member


Date Joined Nov 2010
Total Posts : 7
   Posted 11/19/2010 2:20 PM (GMT -7)   
Thanks for the responses everyone.

I am taking Asacol - 6 pills a day for my UC. I have some cortisone suppositories and some mesalamine suppositories too, used on an as needed basis. I had a 3 week stretch of prednisone use in October, but that's finished (because it didn't help).

I'm using a probiotic, and bromelain, and a calcium supplement and a folate supplement.

And then since I had the flu or whatever this last week I was using immodium.

My UC is primarily proctitis, with one other patch up near my ileum.

The ER doctors did blood tests for something that indicated pancreatitis. Perhaps that is the amylase you are refering to? She said the normal upper limit was 10,000, and mine was 15,000.

Sue - what do you mean by "re-challenged"?
Quincy - what do MRCP and ERCP mean?

I will let you all know what the doctor says.

Thank you everyone!
Laura

suenew61
Regular Member


Date Joined Feb 2010
Total Posts : 103
   Posted 11/19/2010 2:52 PM (GMT -7)   
Hi Laura
My daughter was taken off all oral mesalazine when she was hospitalised with pancreatitis.
When she came out of hospital she was still getting very bloody diarrhea and she used pentasa enemas that had been previously been given, because in theory they should not have been absorbed enough to cause problems. But they did - she flashed fevers and her amylase started to increase again. She stopped them and the fever/amylase settled once more. Some people react to the different formulation ingredients and so by changing brand things can improve - but if you are sensitive to the mesalazine you cannot ever take it again.
Acute pancreatitis can develop quickly and is VERY painful in the upper middle abdomen to the upper left under the ribs. It can be life threatening - and so if you are getting new symptoms of severe pain in that area it is better to get it checked out rather than ‘wait and see’
Sue

Post Edited (suenew61) : 11/19/2010 2:58:19 PM (GMT-7)


quincy
Elite Member


Date Joined May 2003
Total Posts : 29860
   Posted 11/20/2010 1:31 AM (GMT -7)   
Hi Laura...this is a good link regarding drug-induced pancreatitis, diagnosis, testing, etc.  Scroll down...increase the size...worth printing actually and could give you some valuable info regarding questions for the doc.
 
 
 
MRCP:
 
ERCP:
 
Please keep us posted.
q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Ranitidine; Effexor XR 37.5mg (depression), Pulmicort/Airomir (asthma)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care+Primadophilus Reuteri capsules @ bedtime
~Metamucil capsules 6 twice daily with meals; Vitamin D 4000 IU
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!

wahoo
New Member


Date Joined Aug 2012
Total Posts : 1
   Posted 8/23/2012 4:16 PM (GMT -7)   
So I'm 22 yrs old I got pancreatitis, esophagitis, and gastric ulcers
I don't no wat caused it cuz my doctor doesn't no.I'm from Wisconsin. I need help I can't stand the pain anymore.

goincoastal
New Member


Date Joined Jul 2012
Total Posts : 11
   Posted 8/23/2012 9:23 PM (GMT -7)   
I've been on 6MP for 10 years and I remember when I first started my GI warned me of Pancreatitis as a side effect of starting the 6MP but I didn't have that problem thank God. Hope you get this issue resolved.
44 yr old mom of 3. UC for 13 yrs. using colozal 4 2xday, 6mp 50mg 2xday, currently 40mg prednisone. Get all side effects on pred and hate it but it usually works. Would love a big fat piece of cake.

Mybellyhurts
Regular Member


Date Joined Aug 2012
Total Posts : 60
   Posted 8/24/2012 3:44 AM (GMT -7)   
Wahoo: My 8 yr old son has eosinophilic esophagitis...he is on special formula (Neocate) and takes swallowed flovent to help keep his calm.

Did they tell you what kind of esophagitis? They would need multiple biopsies.
Diagnosed with mild proctitis (1st 16 cm). April 2012
Month long bouts of diarrhea for about 5 years now.
Suspected c-diff 2009. Flagyl then vanco / florastor.

Currently on hydrocortisone enemas 2x day
Lialda 4.8 grams
Pred 40 mg then taper by 5 mg every 3 days
Protonix 1 day
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