Urine color change?!

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Regular Member

Date Joined Nov 2010
Total Posts : 47
   Posted 1/28/2011 10:12 PM (GMT -7)   
Okay, so I haven't been on Lialda for that long. (Since about November.) It makes my head hurt; I chug water. I urinate more frequently also, which seems to make sense. Although, I have noticed that sometimes, usually in the middle of the night or the early morning, I will have like light brown colored urine. The past two days in a row, this was the case. I emaile my GI and her nurse responded telling me to go right to my PCP. Since I'm at school, I went to health services. Gave a urine sample, and it came out completely normal? She said it was like perfect. Then they tested my kidney function with some blood test, but the results of that have not shown up online yet.
Has anyone had a similar situation? Light brown urine. I am not dehydrated, I have not begun any new supplements recently, and I haven't been eating anything crazy. What the heck is going on? It's abnormal. I even showed my roommate and she confirmed, normal people do not pee like that.

Is this even related to Lialda?

Any insight would be greatly appreciated! Thank you sooo much.

21-year-old college student

Lialda, 4 per day
gluten-free (working on other diet mods?)
Fish Oil, Vitamin D, Calc/Magnes, B complex, Folic Acid

Regular Member

Date Joined Aug 2010
Total Posts : 157
   Posted 1/29/2011 12:31 AM (GMT -7)   
Hi! I am having a strange colour urine aswell bit mine is not brown it looks fluro yellow which is not normal for me . I have been checked aswell and all clear.. Wondering if it could be liver related so i am looking into it as i have not been feeling well again lately. If the smell of your urine changes or you get a discharge or temp, then i would be going back to the doctor to be checked again. Good luck.

Regular Member

Date Joined Feb 2010
Total Posts : 103
   Posted 1/29/2011 4:06 AM (GMT -7)   
Get several spare urine pots and catch some urine each time till you get a brown one. Then take that one in for examination/measurement. Brown can be a sign of myoglobin which is a product of muscle breakdown. Are you getting muscle pain in addition to the headaches? Mesalazine sensitivity could be the problem and even if the brown colour resolves if you are sensitive further problems can happen. My daughter had several episodes of brown urine and then later developed pancreatitis due to mesalazine.
Daughter(18) diagnosed severe pancolitis Nov 2009
Off all mesalazine following acute pancreatitis
Currently 2.5mg pred
6MP(25mg/day) SCD, Vitamin D, Homemade yoghurt
FSC Ginger, Boswellia & Curcumin
Enerex CoQ10 (enteric with B6 and phosphatidylcholine)

Veteran Member

Date Joined Jan 2011
Total Posts : 599
   Posted 1/29/2011 6:53 AM (GMT -7)   
I've been on my meds for years yet last fall I also experienced brown urine. I was on the tail end of a year long flair, had not changed any meds or diet. It happened twice, once for about 2 weeks and then for a few days about a month apart. The only thing I had had was a Twinrix vaccine but my GP says it had been to much time for it to be the issue??? I told both my GP and my GI neither seemed overly concerned. I researched online and nothing there was reassuring at all... I had just had a full blood work with normal kidney and liver function. I increased water and kept a close eye on it.. just when I was really getting worried, it seemed to go away on it's own... Never did find out what or why. I hope you have the same situation happen (that it goes away quickly).
38yr old female
first symptoms 2006, UC diagnosis 2007, solid remission for 3 years then flare for past year.
Current Meds: 4 Mezavants/day, 4g Salofalk enemas/nightly
Other: Iron supplements, multivitamins, green tea, trying spinach/sunflower seeds for past 2 months.

Regular Member

Date Joined Nov 2010
Total Posts : 47
   Posted 1/31/2011 12:41 PM (GMT -7)   
My kidney function blood tests came back saying completely normal. (Though Im not so sure they checked my liver fxn.) Neither my GI nor my PCP seem to think anything is the matter. Woke up today to go running, went to the bathroom, and there it was again! Today a bit more orangey, but nonetheless messed up. Also, i do not believe that the smell has changed.

Do you think I should go back to the doc, or do you think its nothing? I'm not sure if this is something I should pursue. Then again, it did take me like 5 years to figure out i had UC. :-/

I'm sort of hoping it just goes away. But does this happen to healthy people?!
21-year-old college student

Lialda, 4 per day
gluten-free (working on other diet mods?)
Fish Oil, Vitamin D, Calc/Magnes, B complex, Folic Acid

Regular Member

Date Joined Jul 2010
Total Posts : 445
   Posted 1/31/2011 1:50 PM (GMT -7)   

Urine is made up of excess water and waste products that have been filtered from your blood by your kidneys. Its yellow color comes from urochrome, a pigment that results from the breakdown of hemoglobin, the oxygen-carrying protein in red blood cells.

Discolored urine is often caused by medications, certain foods or food dyes. For instance, the dyes used in some sugary cereals can show up in kids' urine. In some cases, though, changes in urine color may be caused by certain health problems.

Here's a look at possible causes for abnormal urine color:

Red or pink urine
Despite its alarming appearance, red urine isn't necessarily serious. Causes include:

Blood. The presence of red blood cells is the main reason urine turns red. Usually, bleeding isn't severe and occurs without other signs or symptoms. Factors that can cause urinary blood, known medically as hematuria, range from strenuous exercise, urinary tract infections and an enlarged prostate to kidney or bladder stones, kidney disease, and, occasionally, kidney cancer or bladder cancer.
Foods. Beets, blackberries and mom's rhubarb pie can turn urine red or pink.
Medications. Certain laxatives — Ex-lax is an example — can cause red urine. Prescription drugs that have the same effect include antipsychotics such as chlorpromazine and thioridazine and the anesthetic propofol (Diprivan).
Toxins. Chronic lead or mercury poisoning can cause urine to turn red. This may be the result of high levels of excreted porphyrins, the same pigments that discolor the urine of people who have porphyria.

Orange urine
Orange urine is hard to miss. Blame it on:

Foods and supplements. Leading food culprits include vitamin C and carrots and carrot juice. Large amounts of carotene, the orange pigment in carrots, winter squash and other vegetables, can also discolor the palms of your hands and soles of your feet.
Medications. Medications that can turn urine orange include the antibiotic rifampin (Rifadin); the blood thinner warfarin (Coumadin); phenazopyridine (Pyridium), which treats urinary tract discomfort; some laxatives and certain chemotherapy drugs.
Dehydration. Drinking too few fluids can concentrate urochrome, making urine much deeper in color.

Blue or green urine
Blue or green urine can result from:

Foods. Asparagus may give urine a greenish tinge as well as a characteristic odor.
Medications. A number of medications produce blue urine, including amitriptyline, indomethacin (Indocin), cimetidine (Tagamet), the anti-nausea drug Phenergan and several multivitamins. A dye used in several medications that treat urinary pain (Urised, others) can turn urine blue.
Medical conditions. Familial hypercalcemia, a rare inherited disorder that causes high levels of calcium, is sometimes called blue diaper syndrome because children with the disorder have blue urine.

Dark brown or tea-colored urine

Food. Eating large amounts of fava beans, rhubarb or aloe can cause dark brown urine.
Medications. A number of drugs can darken urine, including the antimalarial drugs chloroquine and primaquine; the antibiotic metronidazole; nitrofurantoin, which treats urinary tract infections; laxatives containing cascara or senna; and methocarbamol, a muscle relaxant.
Medical conditions. Some liver disorders, especially hepatitis and cirrhosis, and the rare hereditary disease tyrosinemia can turn urine dark brown. So can acute glomerulonephritis, a kidney disease that interferes with the kidney's ability to remove excess fluid and waste.

Cloudy or murky urine
Urinary tract infections and kidney stones can cause urine to appear cloudy or murky.

New Member

Date Joined Jan 2009
Total Posts : 8
   Posted 2/12/2011 11:37 PM (GMT -7)   
I know I'm late to the topic, but I've been on Lialda for two years now and have also experienced the brownish urine (as well as brownish purple color of the dried "splash back" in the toilet - I have to clean my toilet everyday or it looks disgusting!). Anyhow, the color change is caused by your body metabolizing and excreting the coating on the pills. It's not the actual active medication (mesalamine) just the substance they use to coat the pills. It was good to go into the doctor to have it checked out, but if your urinalysis and blood test came back within normal range, you have nothing to work about.

Veteran Member

Date Joined Mar 2010
Total Posts : 1180
   Posted 2/13/2011 11:15 AM (GMT -7)   
I have had dark urine on sulfasalazine(orange too), Colazal and asacol. My liver/kidney function tests have always been ok when on medication.

i drink a lot more water and it doesn't happen so much

New Member

Date Joined Aug 2013
Total Posts : 1
   Posted 8/14/2013 7:27 PM (GMT -7)   

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