Prednisone doesn't work for alot of people - you are not alone, as you can see from the replies.
I was put on 2 initial rounds of prednisone (together with the mesalamine suppositories, enemas, pills) and it did NOT work for me. They started me on 30 mg for 4 days, then went to 20 mg for 4 days, then 10 mg for 4 days, then 5 mg for 4 days and then none. The side effects were just horrible and no help at all. So you could be one of the may for whom prednisone just doesn't do it.
I am wondering if it's possible that in addition to prednisone not working you may be intolerant of mesalamine? Alot of people are intolerant of mesalamine - especially orally.
It gives them headaches, stomach cramps, and terrible diarrhea (that's what happened to me, and I've spoken with many others who have had the same reaction and when they were taken off mesalamine, some of those symptoms subsided greatly). That might be the case with you?
And if that is the case , then what treatments are possible alternatives? They'll probably try and push the immuno-suppressants, and TNF, perhaps 6mp others.
I"ve refused to take those because the side effects are just too costly. Perhaps you should consider (and forgive my bias here) Transdermal LDN? It's worked wonders for me, and has helped so many others.
Diagnosed with UC in September 2010.Tried various Mesalamine enemas/suppos/pills with Prednisone for several round without any help.Diet consists of only protein: protein shakes w/Maca powder,L-Glutamine 15 grams, D-Ribose 5grams, chia seeds, and meat & fish only.Liquid Minerals& Vitamins. Transdermal LDN is working!!!