I will let you all know how it plays out for me. I take Imuran and started on 200 mg. Once I got my uc under control I was dropped to 150 mg. I added canasa at that point and my colonoscopy showed a normal colon with a small 5 cm patch in the rectum. My doc and I agreed that if the canasa can get this area under control then consider lowering to 100 mg. My goal would be just to use suppositories and not a systemic med but we shall see how it goes. I have a flex scope in about 2 weeks.