I used to order VSL #3 from someplace in California (across the country from where I am), and it used to be shipped with dry ice pack in a padded aluminum foil packet, and it always came pretty warm temp. wise.
But I didn't know any better, and just put it in the frig, and used it without giving it much thought.
Recently I bought the VSL #3 locally and put it in the frig, and started using it - and I was amazed it had a totally different taste - I think the stuff I used to get from Calif. was inactive or through heat had deactivated, whereas the stuff from the local place was Active, and worked much much better.
Maybe you can call the manufacturer and find out what their recommendations are?
Dx with UC in Sept. 2010.Tried various Mesalamine enemas/suppos/pills with Prednisone for several rounds without any help.Diet consists of mostly only protein: protein shakes w/almond milk, Liquid Minerals& Vitamins,Maca powder,L-Glutamine 15g, D-Ribose 5g, chia seeds,5-Loxin.VSL#3,K2,VIt. D3 100,000 IU every 10 days.Canasa suppos. as maintenance. But Transdermal LDN is working!!