Huge connection here. Amazed I have never run across this before or discussed it here.
Does anybody know anything about
this ? I am familiar with both but did not know there was a relationship.www.labome.org/grant/r01/at/immunomodulatory/effects/immunomodulatory-effects-of-arginine-supplementation-in-colitis-and-colon-cancer-7811659.html
In studies beyond those originally proposed, we have studied L-Arg availability in 14 normal human subjects and 22 patients with ulcerative colitis (UC) involving the entire colon (pancolitis). We have found increased serum L-Arg levels in severe colitis vs. moderate colitis or normal controls. There was a strong correlation of serum L-Arg level with the Mayo Disease Activity Index (DAI). In parallel to the increase in serum L-Arg levels, there were also increases in the amino acids L-ornithine (L-Orn) and L-lysine (L-Lys), which compete with L-Arg for uptake into cells by the transporters CAT1 and CAT2, so the net effect was no increase in the arginine availability index (AAI), calculated as the [L-Arg]/[L-Orn + L-Lys]. As a supplement to our Parent R01, we propose to test the hypotheses that there is a functional deficiency of L-Arg availability in UC, and that dietary consumption of L-Arg may be a determinant of L-Arg availability and disease activity..........Over one million Americans have inflammatory bowel disease and about half of those affected have ulcerative colitis (UC), leading many to seek a variety of diets and alternative medicines. In addition to our funded studies under R01 AT004821 studying the importance of the amino acid L-arginine (L-Arg) in animal models, we have exciting new data in humans with ulcerative colitis indicating that there is accumulation of L-Arg in the serum of patients with severe UC, which suggests that there may be a defect in utilization of L-Arg in this disease.
A Study is still underway..
Study of Effects of L-Arginine in Colitis and Colon Cancer
This study is currently recruiting participants.
Verified on March 2011 by Vanderbilt Universityjn.nutrition.org/content/137/6/1693S.full.pdf
Oral supplements of arginine and citrulline increase local nitric oxide (NO) production in the small intestine and this may be harmful under certain circumstances. Gastrointestinal toxicity was therefore reviewed with respect to the intestinal physiology of arginine, citrulline, ornithine, and cystine (which shares the same transporter) and the many clinical trials of supplements of the dibasic amino acids or N-acetylcysteine (NAC). The human intestinal dibasic amino acid transport system has high afﬁnity and low capacity. L-Arginine (but not lysine, ornithine, or D-arginine) induces water and electrolyte secretion that is mediated by NO, which acts as an absorbagogue at low levels and as a secretagogue at high levels. The
action of many laxatives is NO mediated and there are reports of diarrhea following oral administration of arginine or ornithine. Large single doses of poorly absorbed amino acids seem to provoke diarrhea. More research is needed to reﬁne dosage strategies that reduce this phenomenon. It is suggested that dipeptide forms of
arginine may meet this criterion.
That explains why amino acid products dont work for me.
Its not looking too good for arginine right now.
Post Edited (aguywithuc) : 8/12/2011 4:58:10 PM (GMT-6)