There is accumulating evidence that antibiotics (likely some types) are an indirect TRIGGER of UC because they change the gut flora in ways that change the immune system in ways that let inflammation in the colon get out of control. I say TRIGGER instead of cause because other factors (not related to antibiotics) seem to be needed as well.
While I have evidence from a scoping (with biopsies) that I did not have UC just prior to resecting 12cm of my right colon in Nov-2008, by May-2009 I had all the initial symptoms of UC, except bleeding. By Nov-2009, I had the bleeding too, and was diagnosed by scoping in Jan-2010. Not much happened other than the massive doses of IV antibiotics I got post-surgical. So I say that in my personal coherent narrative, I STRONGLY BELIEVE. I refrain form saying I know for a fact, because something I am not attending to may have happened post-surgury or during the following year. Or, something related to inflammation may have been brewing for years. I really suspect some tie to the drug ACTOS and a severe intolerance reaction with all kinds of persistent inflammation and edema during 2006. Maybe it seems like semantics, but to "know for a fact" may be to close ones eyes to new clues/connections that come along.
It is also pretty clear that this is one trigger for some cases of UC - not all cases. So I am always puzzled by those who obviously got to UC by some other (non-antibiotic involved) route, using their anecdotal history to question the vast evidence that some do get to UC due to some involvement of antibiotics. Because SOME do it does not mean that ALL must, nor does it mean the nobody does, just because one does not. We should not try to make things so black-n-white one size fits all.
Post Edited (DBwithUC) : 10/4/2011 12:14:23 PM (GMT-6)