I have split the dose before. I had one doctor who preferred I take 20 mg in the AM and 20 mg in the PM, however I don't like taking it this way and this is the only doctor I had who prescribed it that way. When I split the dose I find the side effects get a lot worse, my moon face, weight gain, ect were all worse when the dose was split instead of one AM dose.
I have since read that it is recommended in most cases if it can be tolerated to only take one daily dose to minimize adrenal atrophy or other long term health problems.
I would ask your doctor or call their nurse before switching it.
Diagnosed with Crohn's in 1998, father has UC we were both diagnosed at 20 yrs old. Diagnosis changed to UC Sept 2011
Meds ~ Proctofoam, 20 mg Prednisone, restarted Humira
Supps ~ Fish Oil, folic acid, magnesium, D3, K2, Vitamin C, B-complex, multi-mineral.