Prednisone & Melatonin

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Regular Member

Date Joined Sep 2011
Total Posts : 62
   Posted 10/22/2011 4:15 PM (GMT -7)   
So I've been having awful insomnia while on Prednisone and bought some Melatonin to try and combat this, but while researching online I'm seeing some sources say that they two shouldn't be taken together, but none of these articles/sources are really saying why...does anyone take Melatonin with their Prednisone to try and get some sleep?

Bacon Girl
Veteran Member

Date Joined May 2011
Total Posts : 5474
   Posted 10/22/2011 8:17 PM (GMT -7)   
yeah i was but it wasn't helping me at all. i was taking 3mg of melatonin at night and still woke up a lot.
severe pancolitis
medications: 10 mg prednisone, 50 mg 6mp, and remicade.
other stuff: 2 packets of VSL#3, calcium, vit D, turmeric, and zinc citrate.

remicade infusion aug 29, 2011, sept 12, 2011, and is oct 10, 2011. next one is nov 30. it's working!

Veteran Member

Date Joined Oct 2011
Total Posts : 683
   Posted 10/22/2011 8:22 PM (GMT -7)   
or alprozolam helped me.125

Veteran Member

Date Joined Oct 2011
Total Posts : 683
   Posted 10/22/2011 8:31 PM (GMT -7)   
You sound in the exact same place as me, I'm at .5 pred, 6mp 50, 75 alternating and was on cipro earlier, and going for my forth Remicade nov. 22. I have been ok too, but I think it is just the pred, starting to see signs more as I ween. I have been on 6mp since Jan. And never saw a difference, was on hydrocort and Apriso at the same time. I stopped all steroids before starting rem to see if it worked and ended up into a bad flare beginning after first infusion, and worsening after second. At the hospital a week later and put on 60 prednisone. I don,t want to mix anything with the rem, bc i want to know for sure if it works or not, I actually don,t really want to take it because of the risks, especially with 6mp combined. What do you think?

Regular Member

Date Joined May 2011
Total Posts : 331
   Posted 10/22/2011 9:10 PM (GMT -7)   
I have been on Prednisone and Melatonin at the same time in the past. But I took melatonin for its anti-inflammatory and anti-apoptosis for Crohn's.

But what helped me the most to fall asleep was LDN.

LDN + Melatonin helped me while on prednisone to get quality some rest. On the first day on LDN, I slept from 1 am to 11 am straight without waking up.
21 male
Pancolitis 2008 Jan. then Dxed Crohn's colitis later
Multiple strictures in 2010

Only on Beck's Protocol and LDN

Quit all medications including, Pentasa, Humira, Entocort and 6mp and Prednisone

Jog 2miles daily
Melatonin/Vitamin D/DMSO/Iodoral/AL Acid/Ultimate Flora/Manuka honey
No HFSC, sugar,msg

Veteran Member

Date Joined Apr 2010
Total Posts : 1353
   Posted 10/22/2011 9:54 PM (GMT -7)   
Melatonin may make immunospressants ineffective when you combine the two.
22 · F · Ont, Canada
Inactive left-sided UC · Remission!
Asthma, seasonal allergies
March 2011 scope indicates 15% inflammation
Salofalk made symptoms worse
Imuran, 100 mg · Alesse · Folic acid, 5 mg · Multi-vitamin, Vit. B, C, D, Calcium
Avoids: red meat, alcohol, high fat, fried, salt, sugar, dairy
Can have: fruits, vegetables, white meat, wheat
Trial and error: Benefiber

Regular Member

Date Joined Sep 2011
Total Posts : 62
   Posted 10/23/2011 4:12 AM (GMT -7)   
Thanks for everyone's input - Sibby that makes sense, melatonin effecting the Prednisone as ineffective...I don't know why nothing said this, haha, thank you!
34 year old female
Diagnosed with Left-Sided Ulcerative Colitis 8/10 - changed to Pancolitis 10/11
Was taking Apriso, now switched to Lialada (4 pills, once a day)
Currently on 50mg of Prednisone for flare which started 9/11
GI thinking of starting me on Imuran soon
Taking probiotics, tumeric, calcium, vit c, multi-vit, fish-oil
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