I have been on Prednisone and Melatonin at the same time in the past. But I took melatonin for its anti-inflammatory and anti-apoptosis for Crohn's.
But what helped me the most to fall asleep was LDN.
LDN + Melatonin helped me while on prednisone to get quality some rest. On the first day on LDN, I slept from 1 am to 11 am straight without waking up.
Pancolitis 2008 Jan. then Dxed Crohn's colitis later
Multiple strictures in 2010
Only on Beck's Protocol and LDN
Quit all medications including, Pentasa, Humira, Entocort and 6mp and Prednisone
Jog 2miles daily
Melatonin/Vitamin D/DMSO/Iodoral/AL Acid/Ultimate Flora/Manuka honey
No HFSC, sugar,msg