I think it is definitely warranted if you can't get below 20mg of prednisone, unless you've been tapering very quickly and that's the reason for relapsing. By quickly, I mean 10mg a week each time. My 2nd taper, I went at 5mg probably every 10 days. I had a lot of difficulties around 15mg and started 6mp with good results. Have you tried using steroid rectals? Have you tried other 5ASAs? Rectals 2x a day? I think it's definitely time to start trying to find something that works for you.
10 months ago I was on 15 mg and rectals, and canasa which worked, and I was able to actually taper all the way down, but within 2 weeks of tapering both pred and rectals, it came right back so went straight to 40mgs with Hycortisone suppositories, and this is where I have been since(trying to get off the pred)...My last tapper I did 40 for three weeks, 30 for a month, 20 for a month, and the second week of 20 I relapsed, so back up to 40. Its getting really frustrated, because I can't seem to find the combo yet that will give me a good remission. I have been in and out of this flair for over a year and a half, and before this I had remission for 8 years!
I have also tried asacol, and sulfasalizine
I haven't tried rectals twice a day because with work monday-friday, Im not sure how I would do the morning Rowasa without it leaking out too much, from the previous night enema? sorry to be gross