I've also noticed that the coloration comes off the generic lialda when my hands are damp and handle the tablets. I make sure my hands are dry 1st, now! Certainly, all of the other 5ASAs/mesalamines I've handled have a very hard coating that seems unaffected by damp hands. Typically these 5ASAs/mesalamines pills are PH activated, so if they are at a certain, predefined PH and sit there for a specific amount of time then the casing begins to dissolve. That usually happens pretty far down within the gut, beyond where you can taste or touch it lol!
I've been doing a bit of research on the zydus generic. Below is a "legal" breakdown of the generic.
This is how Lialda works.
"The tablet is coated with a pH dependent polymer film, which breaks down at or above pH 6.8, normally in the terminal ileum where Mesalamine then begins to be released from the tablet core."
"When the outer, hydrophilic matrix interacts with a person’s digestive fluids, the matrix creates a swollen barrier preventing aqueous solution from reaching the inner, lipophilic matrix. This delay permits the product to proceed through the digestive system until the water breaks apart the outer matrix, releasing the lipophilic granules."
From what I can see, the generic composition is definitely different than Lialda, otherwise they would have lost the legal case of patent infringement to Shire. I have serious doubts about
the effectiveness of the delay function in the generic version. It cannot be exactly the same as Lialda.
In every legal document I have read, magnesium stearate seems to pop up as having something to do with the difference between the 2 drugs.
Refer to the article below if you'd like to read the legal mumbo jumbo.
Post Edited (Glasw55) : 11/21/2017 9:18:15 PM (GMT-7)