I am 39, have been on Remicade for 2 1/2 years now, and still experience the same daunting fatigue many of you are experiencing. I actually found this thread by doing a Google search for Remicade and fatigue! I am self-employed, work over full time most weeks, but try to get as much rest as possible. Unfortunatlely, it doesn't leave much time for anything else, between work and sleeping. It's even become an issue in my marriage because my husband will want to go do things on the weekends and I just want to stay in bed. I know if I don't get my rest, then I risk getting sick and being down even longer. It's a vicious cycle.
I do have depression and been taking Paxil for a number of years. I don't remember having the fatigue with just the Paxil alone. I don't think I have any other conditions, even though I do wonder if I might have fibromyalgia because I'll get these pains in different parts of my body and they just ache and are tender to the touch. Very strange.
If anyone else has any suggestions or advice, I would love to hear it. Glad to hear, however, that I'm not alone!