My issue is this:
Based on my Oct. 2011 scope, I have 0 rectal or sigmoid inflammation thanks to Canasa + Rowasa. I have 0 right sided or transverse colon disease (not even via biopsies anymore - don't ask me how!). The only bit of inflammation I have left is 10 cm in my descending (left side) colon, a little higher than where the Rowasa will reach. The only way to get medicine to that area is via the oral route. This is when the doctor and I decided to start 9 pills of Colazal a day.
Unfortunately, I can't tolerate the higher doses of oral mesalamines without them causing diarrhea like stools and crazy amounts of gas (including the 9 pills of Colozal). I then switched to a "mix" approach and the doctor OKed it. I am still dealing with the gas right now, but with this combination of medicines, it appears that I am "better" in regards to the loose stool. The flip side though is, I don't think that enough of the medicine is getting to where it needs to. Obviously, when the medicine does get there, it works perfectly (see my rectum, sigmoid, right side of colon). This is my dilemma. I am switching to the Mylan today, because of the Colazal brand name issues. So let's see if that helps or hurts me any.
As far as the rectals, I take the Rowasa only 2x a week to maintain. The Canasa I take every day, but it doesn't cause me any issues or problems to take it (besides gas). So I just do it as a matter of habit at this point (I could probably taper down the usage to 2-3x a week).
The calprotectin test - it's been around for roughly 3-5 years, but they are still "proving" it works in trials. My insurance won't approve it yet for it's use w/ UC (considered experimental). However, doctors have ways to get around this! :) It definitely looks like it is the future though for tracking disease activity. If interested, here are some recent studies in regards to the test:
Please let me know if you have any suggestions or tips as I would like to avoid Imuran/6-MP at this point, but I think I have exhausted all possibilities with the 5-ASA drugs the past 3 years and it's just time for me to get on with my life and stop worrying about
Dx with Mild/Moderate Pancolitis (July 2009)
Dx with Mild (10cm) Left Sided Colitis (October 2011)
Apriso 4x a day
Colozal 6x a day
Canasa 1x a day
Rowasa 2x a week
Post Edited (NiRo) : 2/17/2012 10:50:18 AM (GMT-7)