I had a flare-up and now on Prednizone. STarted with 8 a day now down to 2 a day. Over the last two weeks I have had extreme shortness of breath. I am very active, and healthy, doing things including hiking, running, etc. I now can't even climb one flight of stairs without being out of breath. Same thing happened to me last year. Doctor put me on puffers but diagnosed nothing. It eventually went away. This year I'm back on puffers and doctor put me on Nexium. Says it could be an overproduction of acid due to the Colitis. Anyone have this? Kind of scary. I ran a half marathon 5 months ago. Last night tried running 5 km and had to stop three times.