Posted 3/19/2012 12:34 AM (GMT -6)
Thank you for your reply. I hear ya on the don't use the bathroom after me when flaring. Actually everyone knows not to use the bathroom after me even when not flaring. LOL. Strangely my dog has the same problem with gas. So does the cat, especially when company comes over. I'm sure they both secretly hate me after years of falsely being accused of gas issues and being ousted from the room. Not sure if anyone still buys it but it still gets a laugh. and so far from what I'm thinking you may not be all that far off with the increased intensity correlating to increased severity of the flare.
Its the odor that I'm paying attention to right now. It seems putrescine may be the indicator, or even the cause, of a biochemical imbalance.
Here's what I have so far (sorry about the lack of spacing, I'm just going to let it flow)
ODC levels are increased from stress, the more stress the higher the levels. That equals more putrescine made from ornithine (stinky). The main enzyme involved in polyamine regulation is ODC. Increased ODC levels from the stress possibly downregulates polyamine levels. This has the potential to affect bacterial populations as they are large producers of polyamines. Bacterial imbalance is created as the body tries to regulate the production of these polyamines so certain bacterial populations could be targeted if the body sees them as threat to this critical polyamine balance. This trigger could shift the microflora balance around so the bacteria that produce less polyamines are allowed to survive. This can be a major cause of food intolerance and could possibly allow for bad bacterial populations to increase temporarily, thus weakening the mucosa of the colon. This could be one of the reasons why we respond so favorably to probiotic supplements. While damage-repairing polyamines are being held in check, the mucosal lining is not being replenished fast enough.. thus creating bleeding ulcerations. The body's immune system now sees this as a threat and begins attacking the bacteriod infections caused in the perforation of the mucosal lining of the intestine (possibly naturally present B.Fragilis, or even some friendlies, and could be why pathogen testing comes up negative and why pus and mucus are found in stools). That could be why anti-inflammatory and immunosuppressive drugs work so well (polyamines affect gene expression) and why UC is thought of as an autoimmune disorder. The worse the mucosal lining gets, the more colon is affected. As these drugs hold the immune system in check (somewhat), the body is able to naturally resume its polyamine balance and begin healing. The genetic/hereditary component could be attributed to a genetic defect in the ability of the body to resume its polyamine balance correctly.
Thats my hypothesis so far. Its a bit out there right now and in raw form but agree with it or not, I managed to tie it all together with some hard science. Ugh, brain hurts now.
35 yrs old, had this thing since 95 blah blah I hate it
in remission -I know what I'm doing, college grad, researcher, more blah blah
Been away for awhile and didn't die yet, now stronger faster bigger smarter
Coconut Oil, Tons of multi-strain Probiotic Yogurt, lactose n fatfree protein shakes, Metamucil, Hi Glycemic sugars, raw foods, AAKG, oysters, MCTs, wanna know more? just ask