I've had UC for 7 years and have been taking 3000mg/day of Salofalk (4500mg/day during flare-ups) ever since. At first the Salofalk seemed to control my flares quite well...only got flares once a year that lasted for 3-4 weeks. But over the past few years I've gotten 2-3 flares per year and some of them have lasted 2-3 months. I'm currently in a flare that started in mid November with only 2-3 weeks of remission in February. To make things worse, my GI retired and I hadn't had a colonoscopy in 3 years.
I finally got to see my new specialist on Monday and told her how my flares have been getting more frequent and longer in duration over the past few years, and she said she wanted me to go on 40mg of Prednisone and start Imuran at the same time. Her thoughts were that the Salofalk isn't working for me anymore and I need to get out of this flare-up ASAP, hence the prednisone. She says I will only need to be on prednisone for 2 months but the Imuran will be my new long-term medication replacing the Salofalk. She requested some bloodwork and stool samples from me and scheduled me for a colonoscopy right away. That happened today, Friday.
I didn't get to speak to her after the exam, but the note she left was this:Ongoing inflammation, but just at the bottom 20cm - biopsied.
We are going to try to bring you back into remission without suppressing your immune system by using a combination of pills and enemas that coat the rectum to decrease inflammation without getting absorbed. Advantage of this is very few side effects, disadvantage is that it doesn't work in more severe disease. If in 2 months, when I see you in office, you are not totally better, we will need to start prednisone and Imuran.
Bloodwork and stool tests were all normal, which is reassuring.Prescriptions:
-Asacol 800 mg (1 pill 3 times daily, so 2400mg/daily)
-Salofalk enemas 4g for 6 weeks (1 enema at night, so 4000mg/daily)
So I'm a little confused now. I'm VERY happy she has decided to cancel her original plan of prednisone and imuran....but if she thought the Salofalk wasn't working well, why would she prescribe Asacol and Salofalk enemas? I understand the difference between taking Salofalk pills orally and the enemas, but from what I understand, Asacol is quite similar to Salofalk (both mesalamine drugs)...
Any comments would be greatly appreciate. Thanks in advance.
Male, 28yrs old, dx with UC in March 2005
RenewLife Ultimate Flora Critical Care (2 caps/day)
Omega 3 (1786mg/day)
Folic Acid (5mg/day)
Vit C (3000mg/day)
Vit D3 (10,000IU/day)
NFH B-Complex SAP (2 caps/day)
During flares: rear meds as needed, 21mg/day nicotine patch, iron supplement, licorice root extract
Post Edited (twbb) : 3/23/2012 9:25:46 PM (GMT-6)