Question for those who have used Mutaflor / e.coli Nissle 1917 probiotic

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Probiotic
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Date Joined Mar 2007
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   Posted 5/30/2012 2:15 PM (GMT -7)   
I have used it in the past too, and always ended up getting some cramps and liquid D. I tolerate most probiotics - eg VsL3, culturelle (the type that has no inulin), align, reuteri pearls, primal defense, critical colon, s. Boulardi, the list goes on- very very well without side effects... I still have a bunch of old expired mutaflor that I think is still potent in spite of the exp. Date, because it can still give me cramps and D- I was wondering, did any of you other Mutaflor users get these symptoms and then subsequently improve on it? I am thinking about trying it again (starting with the old stuff to test my theory, before travelling to Canada only if it ended up being tolerated later) if that was the case.

therearemiracles
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Date Joined Dec 2006
Total Posts : 3534
   Posted 5/31/2012 7:55 AM (GMT -7)   
Hi Probiotic,
 
I tried it for two weeks no improvement at all. I was so expensive too. I'm just working with Nuticology's Perm a vite and another flora probiotic. I'm going to do a probiotic enema tonight and see if it helps, I've done them in the past, no help that I noticed. Colozal seems to be helping. You sound like me we try something, stop and go back to it right? We are trying so hard to see what works and what will stick!
UC since '05 and DX with chronic Lyme's in 2010, (get tested by Igenix Lab) Colozal,DHEA, Vit b shots, Iron,terramin clay (highly recommended!) You have to be your own advocate in your health. I've been to 18 dr's in 7 years. I'm doing so much better after being treated for Lyme's disease. Please don't rule it out, I did at first and could have saved myself two years of HE double toothpicks

lookforcure
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Date Joined Apr 2012
Total Posts : 513
   Posted 5/31/2012 8:19 AM (GMT -7)   
Probiotic,
I hope you kept Mutaflor in refrigerator.
If you had some bad reactions to Mutaflor before, you can try to take it more slowly. Take 1cap every other day (or just 1 in 3 days) after your breakfast for 1 week and see how you feel. If you tolarate it well, then start taking it 1cap every day after breakfast..
In my opinion if you have a lot of diarrhea after taking Mutaflor, it means you have a lot of bad bacteria overgrowth in you gut and they are getting killed by Mutaflor...It is just too much and too fast for your body. So, if you take your time and slowly introduce Mutaflor into your body, it just might work for you better. Try it. What you have to lose?

therearemiracles
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Date Joined Dec 2006
Total Posts : 3534
   Posted 5/31/2012 8:32 AM (GMT -7)   
I agree with lookforcure, I may try it again too. I forget sometimes that D can be a good sign of things existing the body.

journeytoheal
New Member


Date Joined Aug 2010
Total Posts : 10
   Posted 5/31/2012 8:47 AM (GMT -7)   
Could you and others provide some feedback on your experiences with Mutaflor? I am considering a trip to Canada, but would like to know how others have faired with this probiotic. I am new to the forum, posting that is. I have been a visitor for a couple of years.

lookforcure
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Date Joined Apr 2012
Total Posts : 513
   Posted 5/31/2012 9:50 AM (GMT -7)   
Journeytoheal,
I have posted this info on another thread but I think you and other people need to know this. Before you take a trip to Canada, you might need to consider to take Prescript Assist soil based probiotic. I took Mutaflor, it is an excellent probiotic fro UC. I had a long remission thanks to it while I was on it. Prescript Assist works differently than Mutaflor but there is a lot of research behind it too.
Not many peple heard about it. You do not need to refrigerate it and these bacteria will not die because of the stomach acid. I took it for a while and still have 3 bottles for the future.
Here is some information about it.
Prescript-Assist Probiotic is backed by five years of scientific, doctor-lead, double-blind, peer-reviewed clinical studies. These clinical studies indicate that the unique Probiotic – Prebiotic blend of Soil Based Microorganisms (SBO) found only Prescript-Assist outperformed other popular Probiotics (including Lactobacillus and Bifidobacterium).

Advantages of Prescript-Assist:
•Better survival in the gut
•Out-competes established negative bacteria
•Improves immune system
•Breaks down toxic chemicals

Prescript-Assist Clinical Studies Indicated Scientifically Significant Reduction in the Following Diseases and Symptoms:
1.Irritable Bowel Syndrome (IBS)1,2
2.Nausea1
3.Indigestion / Flatulence14. Colitis1,2
4.Antibiotic Induced Gastritis (during antibiotic therapy)2
5.GI Tract “Reconditioning” (post-antibiotic therapy)2
6.Diverticulosis2
7.Chrohns2
8.Vaginitis2
9.GERD2
10.Human Bacterial-Diarrhea (the most aggressive diarrhea caused by bacteria associated with 3rd world countries)3

http://www.perfectsupplements.com/v/ClinicalExp.pdf
http://www.perfectsupplements.com/v/IBS.pdf
http://www.perfectsupplements.com/v/Diarrhea.pdf
http://www.ncbi.nlm.nih.gov/pubmed/16117982

journeytoheal
New Member


Date Joined Aug 2010
Total Posts : 10
   Posted 5/31/2012 10:05 AM (GMT -7)   
Did you experience the same improvements with Prescript Assist as you did with Mutaflor?

Probiotic
Veteran Member


Date Joined Mar 2007
Total Posts : 2832
   Posted 5/31/2012 10:42 AM (GMT -7)   
I have kept my expired mutaflor in the fridge all this time... Am thinking about the prescript assist too (I do use primal defense on and off, it certainly seems another decent eniugh SBO) - my biggest, concern with Prescript Assist is that it contains prebiotics. Prebiotics have always been an issue for me in the past. If I do try mutaflor again, I woukd certainly do the 1 cap oer 3 days initially. unfort. it's not possible to break up capsules since they are hard shell enterically coated and sealed.
"In order to save the village organ, we had to destroy remove it" -- Doctor's Prescriber's proverb.

lookforcure
Veteran Member


Date Joined Apr 2012
Total Posts : 513
   Posted 5/31/2012 10:43 AM (GMT -7)   
I was not as sick when I took Prescript Assist, so it is hard for me compare them. When I took Mutaflor I was in a lot of pain, had a lot of bleeding and running to the bathroom 12-15 times per day. By the end of the 1st week the pain was gone, trips to the bathroom diminished day by day and the bleeding has stopped by the end of the 1st month.
With Prescript Assist it was more slow improvement, but I did not have more than 8 BMs per day. Still I think it works better than VSL3 because it actually gets to the colon. I personally got diarrhea and a lot of gas from VSL and had to start very slow with it. On another hand, Prescript Assist did not give me D or gas, but helped to calm my body down.

Indycat23
Veteran Member


Date Joined Apr 2011
Total Posts : 661
   Posted 5/31/2012 11:07 AM (GMT -7)   
Does anyone know what stores sell mutaflor? I live right on the border and can easily drive across the border to pick some up.
_______________________________________________
Pancolitis Diagnosed 3/2011
Prednisone-tapering off
Asacol-800mg x6----Remicade
VSL Daily
Canasa Nightly
Eliminated excess sugar

lookforcure
Veteran Member


Date Joined Apr 2012
Total Posts : 513
   Posted 5/31/2012 11:08 AM (GMT -7)   
Primal Defense has some soil based probiotics in it, so if you could tolerate it well and Mutaflor will not "agree" with you again I would try Prescript Assist. By the way, as far as I know Primal Defense has some prebiotic in it too. Another thing Rubin made some big changes to his original formula of this probiotic in order to save some money, so it is not as effective as it used to be. He removed a few very good and expensive for him ingredients. So, in many ways Prescript Assist is a better choice then Primal Defense.
The special coating on the Mutaflor capsules is a very good thing. This is what helps it to make it to the colon alive.

cherchezlafemme
Regular Member


Date Joined Aug 2010
Total Posts : 213
   Posted 5/31/2012 11:43 AM (GMT -7)   
Hi there,

I've tried Mutaflor a number of times and while it alone won't get me into remission, it seems to do a decent job of keeping me there once I've reached remission. I have big issues with compliance, so at one point or another, I always fall off the meds wagon. It's also kind of a pain to keep up - pricey and the whole 'must stay cooled' thing.

I never noticed any gas, diarrhea or the like while on it, though I've been told (and the instructions suggest) to start slow in case you do get uncomfortable symptoms.

lookforcure
Veteran Member


Date Joined Apr 2012
Total Posts : 513
   Posted 5/31/2012 1:00 PM (GMT -7)   
Indycat23,
the best wat to find out where you can buy Mutaflor in Canada is to call the company and ask them. I do not know if pharmacies would carry this kind of probiotic, but who knows.

IamCurious
Veteran Member


Date Joined Jan 2010
Total Posts : 3074
   Posted 5/31/2012 1:12 PM (GMT -7)   
I took E. Coli Nissle in Mutaflor for over a year before the FDA banned sales in the U.S. I found it helpful but not more so than VSL#3DS or Culturelle. Those are my two favorites. Everyone is different so don't worry if a particular probiotic does not seem compatible with every individual.

This is from a very recent thread and may explain why a probiotic that works for one may not work for everyone else:
Imagardener2 said...
This article www.sciencedaily.com/releases/2011/04/110420143620.htm indicates that people may have different gut types, meaning different types of predominant bacteria in their gut.

Male/60 DX ulcerative colitis Feb08, or maybe Crohn's colitis.
No Meds, allergic to Mesalamine. Remission since Mar10. Psyllium seed mixed with VSL3 is very helpful. Food journal instead of SCD.

Lots of fruit & vegetables (but no plums, kale, or carrots), no soda, no gluten, no HFCS, no xylitol or sorbitol, no trans fat, no shellfish, few processed foods, no carrageenan.
Probiotics, fish oil, multivitamin, extra D3, K2, high gamma E, phos choline, magnesium, boswellia, curcumin, glutamine.
Nature created all of the locks, therefore Nature has all of the keys

journeytoheal
New Member


Date Joined Aug 2010
Total Posts : 10
   Posted 5/31/2012 1:27 PM (GMT -7)   
Indycat23, I know you can purchase Mutaflor through Amazon. A store in Canada will ship it (through Amazon, not sure how this is the case), but can't guarantee its potency because it takes about 3-5 days to ship. It may be shorter time for you because you are so close to the border. I contacted the manufacturer, medical futures (i believer that's the name) and they will ship to any hotel in Canada. They are located about 20 minutes outside Toronto.

lookforcure
Veteran Member


Date Joined Apr 2012
Total Posts : 513
   Posted 5/31/2012 1:52 PM (GMT -7)   
Guys, I have found an interesting research about S. Boulardii.

..."Non-pathogenic yeasts present some characteristics
that differentiate them from other probiotics. The natural
resistance they have to antibiotics has constituted an
interesting basis for their application as probiotics. In
this regard, Saccharomyces boulardii was the most widely
tested in experimental and clinical assays, showing very
important results.
This microorganism was initially isolated from Indochinese
fruits (lychee). Fruits contaminated with Saccharomyces
boulardii were used in the local popular medicine
for the treatment of diarrhea. A product containing
this microorganism was introduced in France with the
same objective in 1950, and in the present days (Ultralevure,
Biocodex, Monterouge, France) it is widely commercialized
in European, African, and South American
countries. It is generally administered in lyophilized
powder, corresponding to approximately 3·1010 cells/g.
Unless exogenously administered, S. boulardii is not found
as part of the intestinal microflora of laboratory animals
or of humans, and under normal conditions, it does not
permanently colonize the gastrointestinal tract when
orally administred, and is eliminated within 24–72 hours
if not reinoculated (10).
The pharmacodynamics of S. boulardii involves three
different aspects: (i) a direct antagonistic effect on enterobacteria
and other yeasts, (ii) an antisecretory effect
by acting specifically on the binding of toxins to intesnal receptors, and (iii) a trophic effect by stimulating enzymatic
activities and intestinal defense mechanisms
(11). Besides, S. boulardii can also destroy the receptor
site for Clostridium difficile toxin A and B by producing
protease (12), it is thermotolerant and grows at the unusually
high temperature of 37 °C. The taxonomy of the
genus Saccharomyces based on phenotypic and genotypic
methods has been revised several times over the years
and now, using microsatellite polymorphism typing, allows
to discriminate S. boulardii from other strains of S.
cerevisiae (13). In contrast to lactic acid and bifidobacteria,
S. boulardii is naturally resistant to antibiotics (14)."...

From:
http://www.ftb.hr/files/journals/1/articles/694/public/694-686-1-PB.pdf

Probiotic
Veteran Member


Date Joined Mar 2007
Total Posts : 2832
   Posted 5/31/2012 3:34 PM (GMT -7)   
Good s boulardi isnt cheap, but I currently take around 1000 mg a day.. i think I may try surging it some more amidst my other probiotics. Definitely has some supportive clinical data, and is perhaps the best to take if one ever has to take antibiotics.

lookforcure
Veteran Member


Date Joined Apr 2012
Total Posts : 513
   Posted 5/31/2012 3:48 PM (GMT -7)   
You can get S. Boulardii 90 cap. for $20-$30, depending on the brand. It is much cheaper then Mutaflor, Prescript Assist, Dr. Ohhira or VSL.

journeytoheal
New Member


Date Joined Aug 2010
Total Posts : 10
   Posted 5/31/2012 4:04 PM (GMT -7)   
Thanks for the information. There are a lot of positive reviews of this probiotic. Seems to be one of the better probiotics for people with IBS and IBD

lookforcure
Veteran Member


Date Joined Apr 2012
Total Posts : 513
   Posted 5/31/2012 4:41 PM (GMT -7)   
Just one thing you need to know. Not everybody can tolerate well this probiotic. It is yeast, so it can cause gas, bloating, diarrhea, cramps..
It did not "agree" with me personally and I know a few people on this forum had the same problem with this probiotic. Also, because it is yeast probiotic there is more chances for a bad reaction to it.
I think you need to know this. Comparing to Mutaflor, I do not know anybody who actually went into remission just thanks to S. Boulardii. Mutaflor on the other hand, can put a person with UC in remission.
I am one of these people.

Probiotic
Veteran Member


Date Joined Mar 2007
Total Posts : 2832
   Posted 6/1/2012 3:18 AM (GMT -7)   
I was looking at Mutaflor's pamphlet online and see that they have a product with a smaller dose, called "Mutaflor Mite," designed to help acclimitize the gut for those who initially have tolerance issues with Mutaflor- does the Canadian distributor sell this too? Strangely, I have never had any tolerance issues whatsoever with s. Boulardi, but did have to abandon Mutaflor each time I tried (but I now think the trick would be getting Mutaflor Mite for initial use).

lookforcure
Veteran Member


Date Joined Apr 2012
Total Posts : 513
   Posted 6/1/2012 6:53 AM (GMT -7)   
Probiotic,
I have never heard of or seen online Mutaflor Mite. It might be hard to get, even harder than regular Mutaflor. If they have it somewhere it is probably in Gemany, where Mutaflor is made.
It is so annoying that FDA had to stick their nose and stop the selling of Mutaflor in the USA. They did a big disservice to a lot of sick people.

Ilian
New Member


Date Joined Jun 2013
Total Posts : 2
   Posted 6/24/2013 2:50 AM (GMT -7)   
Guys, I just wonder how many of you are still using Mutaflor and do you use some medications with it. I was recently diagnosed with UC and wonder which way to go...My symptoms are not severe and I can afford to wait to make the right decision.

little.b
New Member


Date Joined Mar 2014
Total Posts : 1
   Posted 3/16/2014 2:28 PM (GMT -7)   
Just in case anyone is able to get their hands on some mutaflor suspension from Germany or figure out a way to use the pills to make this, apparently mutaflor can be cultured at home just like yogurt! I haven't tried this but it sounds a whole lot cheaper.

http://www.drmyhill.co.uk/wiki/Growing_Mutaflor

Guardian7
Veteran Member


Date Joined Apr 2006
Total Posts : 2682
   Posted 3/16/2014 2:30 PM (GMT -7)   
little.b said...
Just in case anyone is able to get their hands on some mutaflor suspension from Germany or figure out a way to use the pills to make this, apparently mutaflor can be cultured at home just like yogurt! I haven't tried this but it sounds a whole lot cheaper.

http://www.drmyhill.co.uk/wiki/Growing_Mutaflor


Yes! Thank you!
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