Hydrocodone ABSOLUTELY cures my colitis! I am so glad to see this discussion! I am like many posters here in that the regular meds were not working. I would get some relief but I never went back to normal. The best that the typical UC drug regimes would do is stop my bleeding and get me down to 6 BMs and daily D.
I NEVER had a day that the rest of the world would consider normal.
Then I had dental surgery... From about my second Lortab I had no UC symptoms. I didn't connect it to the Lortabs at the time but I keep a really detailed food /mood/exercise/water/habits diary and have for years. I feed the data into a analytic program trying to make sense of why I get sick/sicker/sickest... Most of the time I get common sense answers; days I stress or drink less water I will bleed or be sicker, sneaking a sip of wine gets me sick, eating chocolate will put me into a flare I can't get out of easily, things I love like swordfish get me sick, etc... That is not news to UC sufferers...
Then I wrecked my knee a couple years later. A few Lortabs later I was COMPLETELY SYMPTOM FREE! I still didn't connect it to the lortabs but my data analysis program did. All the sudden I saw a new connection for a well day... It said Lortab. How weird I thought... It must be from pain relief or something. I am usually in some degree of pain but the Lortabs take it all away.
So fast forward another year. I have cosmetic surgery and get a Lortab prescription again. Two pills in my uc was cured... This time I remembered the connection and I started researching it.
I actually hate Lortabs, I hate pain killers in general but Lortabs just make me feel spacey. I usually take half or 1/4 of the prescription. Because of that I had a few extra pills to test my theory.
Sure enough, if I was taking a Lortab my UC went away. It is not from the fact that Lortab change the absorption or water in your intestines because I tried the same thing with Loperamide which is prescribed solely to change the water absorption in your intestines and while loperamide would reduce BMs I would still be bleeding and in pain. Also, the minute I stopped loperamide my UC returned. With Lortab, I could take it at bedtime and once in the day for about 7 days and live normal. If I did 14 days I would be cured for about 4 weeks after stopping. No uc drugs at all, just cured.
So I brought all my research and information to my Dr. Who, while he acknowledged he had heard of this from other patients, felt that hydrocodone is too dangerous to play with for off label prescribing. I agree, I don't get addicted to it but we have a friend who was the most normal, never done a drug in his life guy, until his knee surgery... He became addicted physically to Lortab from the second pill. It was horrible. He didn't take them for more than 90 days and he had full detox symptoms. Anyhow, I wanted the cure from hydrocodone but not the opioid.
I started to research it and I found that the cure from hydrocodone for UC may come from the endorphin receptors. Hydrocodone ties up the endorphin receptors fooling your body into making more endorphins- or at least that's one of the things it does. Low dose naltrexone does the same thing without the addictive opioid history of hydrocodone. Neuropeptides play a huge role in inflammatory bowel disease and are both present in the intestinal tract as well as regulate immune responses of both the large and small intestine. Low dose naltrexone reduces the inflammatory interlukins and has been show to CURE both UC and crohns in 24 weeks. In simple speak, low dose naltrexone does stuff that stops your body from attacking itself. All of the UC and crohns drugs on the market do not address the endorphin and opioid receptors but work on reducing white blood cells in various methods. Reducing your white blood cell count is the reason why most UC have reduced immune systems and become susceptible to other diseases.
I showed all of my stuff to my doctor but he said that low dose naltrexone being prescribed for uc is still off label and he wouldn't do it but he has referred me to a couple of physicians who work with naltrexone. Unfortunately, one is a methadone clinic for recovering users and the other is a pain management firm where they tried to get me to keep taking my Lortabs for my knee even when I said I didn't want to. (they threatened to cut off my physical therapy).
I am looking for a Doctor who is familiar with low dose naltrexone for UC as I have heard great things. If anyone e has any more tips about hydrocodone, naltrexone and UC please let me know.