I have a new GI doctor. He says that I've been on the maximum dosage of Asacol HD 1600 mg 3x a day for awhile now and I should probably try to cut down the dosage due to possible side effects. BTW It took me two years to finally get the UC under good control. So I went from 4800mg a day to now taking 800 mg a day. 400 in the morning and 400 in the evening. I've been on this dosage for about three weeks. I've been having all kinds of problems from urgency to bleeding to watery stools to ACCIDENTS. Told him about it and he said to stay on 400 mgs twice a day because it takes time for your body to adjust. I'm wondering just how long does this take??? I'm back to taking Imodium because I have an hour ride to work. Does this sound right to anyone who really knows? I'm just upset because of all that I went through to finally having some sort of life without worrying about the close proximity of a toilet.