natural tnf inhibitors

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Bacon Girl
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   Posted 1/22/2013 4:39 PM (GMT -7)   
i was just browsing on the web as i normally do and found this list of tnf inhibitors. i know a lot of us have tried tnf inhibitor drugs and have problems with them. i'm sure you guys have heard of most of this list, but i figured i'd post it for people who are new.

1. Fish Oil. It's no secret that omega-3's are one of your most potent inflammation fighters and studies have shown this to be true in the case of tnf as well. In one study of healthy volunteers, tnf-alpha synthesis was dramatically reduced by 74% as fish oil dosage was increased to about 9 grams per day. [1] NOTE: This is a hefty dose and higher than what is normally recommended for typical fish oil supplementation. Going with a smaller dosage should result in significant reductions according to this study.

2. CoQ10. A number of studies have shown that this antioxidant molecule reduces tnf levels.

3. Mediterranean Diet. One study the degree of adherence to a Mediterranean Diet was inversely related to TNF-alpha levels. [3] In other words, the more the Mediterranean Diet, the less the tnf.

4. Turmeric / Curcumin. Many studies have shown that this spice, present in yellow mustard and curry, inhibits TNF production. [4]

5. Green Tea / EGCG. EGCG is one of the most potent of all plant phytochemicals and has a host of miraculous properties. Multiple studies show that EGCG limits TNF-alpha production. [5]

6. Vitamin E / Alpha Tocopherol. This vitamin not only limits TNF release in arteries but also prevents oxidation of LDL and many other processes that lead to arteriosclerosis. [6] Although scientists have studies alpha tocopherol, it is probably prudent to only take mixed tocopherol Vitamin E because the alpha form can lower levels of the others (gamma, etc.).

7. Ashwagandha. This traditional ayurvedic herb has been shown to reduce TNF-alpha output.

8. Magnesium. There is strong evidence that low magnesium levels can negatively affect TNF levels. [8] Of course, one can easily get enough magnesium from a well-rounded, plant-based diet, but still many in modern societies do not.

10. Tart Cherry Juice. This cherry juice is, well, tart, but is well worth the effort as it tightly clamps down on rising TNF alpha levels. It is so powerful at controlling inflammation that is can reduce post-exercise muscle soreness and is used by many athletes already. 

11. Progressive Muscle Relaxation (PMR). One of the most powerful ways to control TNF alpha levels is actually not a food, juice or supplement but rather a time-proven relaxation technique. PMR was developed originally as psychological tool but has since proven itself to help with many health-related issues.

NOTE: TNF alpha is not the only cytokine that needs to be controlled.  In addition, many foods and a number of supplements favorably alter the upstream TNF inflammatory signaling.. Alpha lipoic acid and an extract of Korean Ginseng are examples of this. [10][11] [12] It should be noted, though, that other extract of Ginseng have actually stimulated TNF-alpha itself. [13] Quercetin, the miracle phytochemical in apples and onions, is also in this category.

CAUTION: The only potentially negative affect of cocoa that I know is that it does seem to stimulate TNF-alpha. [9] The same thing has been found in certain Korean Ginseng extracts as well. [12]


here's the website:


ps- me and somedude will try the entire list at once and post our results.

Joanna, 23
Currently: 3-6 loose bms a day (7-8 on bad days) urgent and gassy
humira, vit D, coconut kefir, cod liver oil, astaxanthin, magnesium,
b12 shots, spatone iron, vit C, colostrum, interfase enzymes,
Tried: canasa, rowasa, entocort, pred, 6mp, remicade,
lialda, welchol, bentyl, LDN, cipro, flagyl, VSL/Vit E enema,
8 FT, clay, aloe vera, slippery elm
diet: paleo/scd

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   Posted 1/22/2013 4:42 PM (GMT -7)   
remicade, a tnf inhibitor and as natural as your uncle Carl.
DX Ulcerative Colitis (pancolitis) - May 2011. (Remicade Max/6 wks, LDN, SCD, vitam.)

"Life is like a box of chocolates; you never know what you' gonna get. " by Forrest Gump

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Date Joined Aug 2012
Total Posts : 9088
   Posted 1/22/2013 4:43 PM (GMT -7)   
Very helpful and interesting. Thanks for posting.
Asacol 400mgs 2 pillsX3; VSL#3 112.5mgs 1 pillX3; Vitamin D3 5000 ius 1 pillX2; B6 1/day; Bentyl & Swanson DAO with meals; Slippery Elm at bedtime

Discontinued: Robinul; Natural - peppermint oil, Inflaguard (Boswellia), Pepto Bismol, Omega 3 fish oil, Imodium, Beano, Zymactive, Renew Life Probiotic 80 billion, Florastor, DGL, Monolaurin

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   Posted 1/22/2013 4:50 PM (GMT -7)   
My daughter takes many of these. What's the Mediterranean diet? I don't think it exists. The Greek diet is very different from the Spanish and the Italian (which may be better than the standard American but isn't that great).

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Date Joined Feb 2003
Total Posts : 1944
   Posted 1/22/2013 9:57 PM (GMT -7)   
I'm a long time user of magnesium and vit E. The more magnesium that I take, the worse the diarrhea is?

Be advised that taking a few natural food sources of TNF inhibitors here and there, will not have the same affect as Humira which is a far more potent inhibitor. Nature puts it in these foods in smaller doses. Does Humira work right away, then the food sources won't either? I find it interesting though, to combine a few of these foods, supplements, and take them for a couple months and see if there are any improvements?

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   Posted 1/22/2013 11:00 PM (GMT -7)   
Very very very interesting. Thank you!
UC Forum Moderator

Ulcerative Colitis diagnosed Oct 2007. Prednisone for flares until Oct 2012. Half-remission from Remicade.
Currently on: Prednisone 20 mg, Imuran 50 mg, Remicade 300 mg (4 infusions)
Supplements: Ultimate Flora x 1, L-glutamine 1000 mg x 1, VSL #3 x 1

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Date Joined Jan 2013
Total Posts : 1037
   Posted 1/22/2013 11:08 PM (GMT -7)   
Thanks so much for posting this. I was just considering going on vitamin e because I saw it on many signatures here. This put me over the top.
30 year old female. 2007 diagnosed with UC, also have Hypothyroidism, Leukocytosis, Agoraphobia, Bipolar tendencies, Panic disorder, Acid reflux, Lactose intolerance, Eczema, Migraines, Degenerative disk, Hypertension, and Anemia.
Lialda, Canasa, Hyoscyamine sulfa, digestive advantage lactose defense, lomotil, klor-con20, started Humira 12/31/12

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Date Joined Jun 2010
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   Posted 1/23/2013 1:35 PM (GMT -7)   
Thank you very much.

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   Posted 1/25/2013 1:38 PM (GMT -7)   
If ALA "favorably alter the upstream TNF inflammatory signaling"

Why is it not listed as item #12 ?

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Date Joined Dec 2006
Total Posts : 3524
   Posted 1/25/2013 1:41 PM (GMT -7)   
Thanks Joanna for taking the time to help and post this :)

Bacon Girl
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Date Joined May 2011
Total Posts : 5474
   Posted 2/1/2013 9:09 PM (GMT -7)   
i just bought some green tea extract today. i want to start taking it but am not sure of the dosage. most of what i find online is about taking green tea for weight loss. does anyone take this or have an idea of how much is ok?

i found this website:

it says to take 100-750 mg a day but on some bodybuilding websites it's 1000-1500 mg a day.
Joanna, 23
Current: 3-6 loose bms/day (7-8 on bad days) urgent/gassy
humira, vit D, coc. kefir, CLO, astaxanthin, b12 shots, spatone iron, vit C, colostrum, interfase enzymes,scdophilus
Diet: SCD/paleo. yogurt, broth, meat, coconut oil, greens, veggies, fruit
Tried: canasa, rowasa, entocort, pred, 6mp, remi, lialda, welchol, bentyl, LDN, cipro, flagyl, VSL/Vit E enema, 8 FT, clay, aloe, slip. elm

Regular Member

Date Joined Jul 2012
Total Posts : 210
   Posted 2/2/2013 4:41 AM (GMT -7)   
I take 500mg per day which is one cap of the following...

Meridian Naturals GTE. Standardized to 225mg of EGCG.

I have doubled that at times without negative effects. There is a small amount of caffeine so perhaps not good to take too late in the day.
Left side UC diagnosed 2009
SCD since March 2011
Meds - Colazal, Rowasa, LDN
Supplements - D 5000IU, E 1000IU, Fish Oil, Multivitamin, ALA, Amer. Ginseng
Probiotics - SCD Yogurt, Kefir, Sauerkraut, Kimchi, 299v, L GG, BC30

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Date Joined Jun 2010
Total Posts : 3006
   Posted 2/2/2013 5:50 AM (GMT -7)   
I always take ECGC because it is also a blood thinner clot preventer.

Anyone care to take a shot at my question above regarding ALA ?

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Date Joined Sep 2011
Total Posts : 1989
   Posted 2/2/2013 2:09 PM (GMT -7)   
Thanks bananagirl:)
Diagnosed Crohns-Colitis Sept 2011
Gluten Free-Limit Grains+Sugar, VSL#3, InflaGuard, Zyflamend, Asacol, Wise Woman Supps#2, iron, similase
Metametrix Labs stool testing reveal yeast overgrowth/parasite & h.pylori

Bacon Girl
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Date Joined May 2011
Total Posts : 5474
   Posted 2/2/2013 5:39 PM (GMT -7)   
thanks sean. i have the liquid extract and used a dropper. one serving is 2,000 mg and i took 500 mg to start out. also took it around 3 pm so i shouldn't have any more of a problem sleeping.

aguywithuc, i found this good info for ALA and also this link

Alpha Lipoic Acid: The Natural Anti-Inflammatory

Unlike Vitamin C, which is water soluble and Vitamin E, which is fat soluble,
Alpha Lipoic Acid is a unique antioxidant that is both water and fat soluble,
which allows it to enter all parts of the cell to neutralize free radicals.
Alpha Lipoic Acid contributes to and is important for the production of energy
inside the cell by utilizing sugar to produce energy contributing to mental and
physical stamina, reducing muscle fatigue and neutralizes free radicals. Alpha
Lipoic Acid recycles and enhances the effects of both Vitamin C and Vitamin E.

Scientists first discovered the importance of alpha lipoic acid in the 1950s,
and recognized it as an antioxidant in 1988. It has been the subject of research
around the world, some being done at UC Berkeley by Dr. Lester Packer, a leading
expert in the area of antioxidants and a professor of molecular and cell biology
at the University of California at Berkeley. He believes that Alpha Lipoic Acid
could have far-reaching consequences in the search for prevention and therapy of
chronic degenerative diseases such as diabetes and cardiovascular disease.
Because it's the only antioxidant that can easily get into the brain, it could
be useful in preventing oxidative stress and damage from a stroke. [21].

Alpha Lipoic Acid is easily absorbed when taken orally and once inside cells is
quickly converted to its most potent form, dihydrolipoic acid. Because both
Alpha Lipoic Acid and dihydrolipoic acid are antioxidants, their combined
actions give them greater antioxidant potency than any natural antioxidant now
known. This also makes it important for regulating aspects of the immune system,
in particular, T-lymphocytes. [22].

The incidence of inflammatory diseases such as arthritis increases with age.
Free radicals promote inflammatory reactions, which antioxidants have been
successful at diminishing.

Scientists recently stimulated the inflammatory response of white blood cells,
resulting in an increase of Intracellular Adhesion Molecule 1 (ICAM-1), which
encourages white blood cells to stick to other cells, thereby inflaming tissues.
Alpha-lipoic acid, a potent antioxidant, was then added to the mix. Researchers
said the acid reduced the activity of ICAM-1 to levels in normal, un-stimulated
cells in a dose-dependent manner. It also lowered the activity of NFkB.
According to the study, these changes suggest that alpha-lipoic acid may help
reduce the effects of inflammatory diseases such a rheumatoid arthritis and
psoriasis. [23].

Suggested dosage for Alpha Lipoic Acid is 100-200 mg in divided doses daily.

SIDE EFFECTS: with alpha lipoic acid are rare but can include:

• Skin rash and the potential of hypoglycemia in diabetic patients.
• People who may be deficient in vitamin B1 (such as alcoholics) should take
vitamin B1 along with alpha lipoic acid supplements.
• Chronic administration of alpha lipoic acid in animals has interfered with the
actions of the vitamin, biotin. Whether this has significance for humans remains
Joanna, 23
Current: 3-6 loose bms/day (7-8 on bad days) urgent/gassy
humira, vit D, coc. kefir, CLO, astaxanthin, b12 shots, spatone iron, vit C, colostrum, interfase enzymes,scdophilus
Diet: SCD/paleo. yogurt, broth, meat, coconut oil, greens, veggies, fruit
Tried: canasa, rowasa, entocort, pred, 6mp, remi, lialda, welchol, bentyl, LDN, cipro, flagyl, VSL/Vit E enema, 8 FT, clay, aloe, slip. elm

Veteran Member

Date Joined Apr 2010
Total Posts : 1353
   Posted 2/2/2013 8:05 PM (GMT -7)   
It does exist.. Consists of Greece, Spain and Italy diets.

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Date Joined Dec 2009
Total Posts : 2396
   Posted 2/2/2013 8:20 PM (GMT -7)   
Sibby, my husband's from Rome and trust me they eat tasty food their but it's in no way healthy from an IBD diet perspective (or what we think of one). And his family eat well with lots of fruit and veg etc. Also, the diet in the North or even the center is very different from that of a place like Sardinia. And the Greek diet is very different from the Italian. Spanish as well. So, nope I don't believe there is a "Mediterranean diet" - it's just one of those empty slogans people use. And AI disease is pretty high in Italy as well. Probably not as high as here but still - within our immediate circle of friends and family there we have severe asthma, three UC, one CD (only one of those is related), lupus, arthritis etc.

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Date Joined Apr 2010
Total Posts : 1353
   Posted 2/2/2013 9:22 PM (GMT -7)   
I understand, but dietitians have called it the Mediterranean diet.
23 · F · Ont., Canada
Inactive pancolitis UC · Last scope: Mild rectal inflammation
Asthma, lactose intolerant, IBS, migraines
5 asa intolerant, Imuran - low wbc
LDN, 2mg · Alesse 21 · Folic acid, 5mg · Inderal, 10mg · Multiple vitamins
Temp: Cipralex, 10mg, Doxepin, 30mg
'Paleo' diet · with potatoes, peanut butter
Refuses biologics and delusional bs

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Date Joined Sep 2011
Total Posts : 4
   Posted 5/19/2015 3:09 PM (GMT -7)   
Stop eating anything with carrageenan, soy, soy lecithin, or and artificial sugar.

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Date Joined Jul 2013
Total Posts : 607
   Posted 5/19/2015 5:06 PM (GMT -7)   
Thanks for posting this. It's very helpful.

I'll take this opportunity to get on my soapbox again and tell people that curcumin can work but to find out if it works for you, you have to take it in high doses. It's my maintenance drug but to stay in remission I Take 3 GRAMS per day. Anything below 1 or 2 grams, minimum, will probably have little effect.

Of course, as with anything, start at a low dose to make sure it doesn't have negative side effects. But ramp up quickly if it agrees with you.
F, mid-40s. Diagnosed early 30's. Grandfather and 1st cousin also had UC.

Daily: 3 grams Doctor's Best Curcumin (6 g while flaring), 4 TBSP resistant starch (potato starch), vit D, folic acid, other B vits, Wellbutrin 450 mg/day, Prevacid 2x/day, Olympian Labs 400 mg grape seed extract 2x/day, Align, Culturelle, 5 oz of yogurt.

Can't tolerate 5-ASAs, Remicade, or psyllium seed powder

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Date Joined Aug 2012
Total Posts : 9088
   Posted 5/19/2015 5:45 PM (GMT -7)   
I'm getting there with a nopal supplement. Been taking it at exremely low dosages. So far notta much of anything. Been taking one, now two capsules per day. Max dose is six. I'll have to ramp it up soon and if still nothing, off to the trash heap it goes.
Pentasa (500mg) 2 pills X 2; VSL 1 pill X 2; Prescrip Assist Probiotic 1 pill X 2; Grape seed extract (1)400mg X 3; Vitamin D3 (1) 5,000 IU X 2; daily generic Allegra; DAO as needed due to dietary histamine intolerance

Gave me trouble: Zymactive, Renew Life Probiotic 80 billion, Florastor, high histamine foods

Regular Member

Date Joined Apr 2015
Total Posts : 348
   Posted 5/20/2015 7:14 AM (GMT -7)   
I've been taking tumeric and alpha linoic acid for a while now, in conjunction following SCD.  Am in technical remission, but have alway had loose stools and pain after eating and have quite bad autoimmune arthritis.  At first it seemed to be working very well, with noticeable steady improvement to stools and back pain week on week.  Had to stop following the SCD while traveling for work and now can't seem to get back to where I was--stool loose again, back very painful.  As always, the ups and downs of this are hard to make sense of.  Could be the diet and supplements weren't making things better, I was just having a few good months. 
I find SCD a bit psychologically challenging as well. If it's not working the advice seems to be to remove yet more food types from your diet.  Might be sound advice, but at some point it starts to seem absurd.
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