Posted 12/26/2013 2:22 PM (GMT -7)
well.....if you go to interpretome.com, and load your 23andme data, they give you a list of your possible variants and those are run against the GWAS database which is the Catalog of Published Genome-Wide Association Studies. I told them I had NO history of breast cancer...which is true, based on my maternal side of the family, and yet I was very high risk for that. I will add though, that BC in women is 12.5% which is pretty high. I mean, you live long enough, you are going to get cancer of some sort! I did not tell them that I had glaucoma, yet I have two risk markers for that. Plus I was a carrier for something for which I had no idea (again, I don't have little info on paternal side of family.) That being said, they did find and correctly ID an aunt of mine and I had no awareness of her at all. That was a BIG surprise! And my aunt has some of the same high risks that I do, including ulcerative colitis, which has not been seen on my maternal side of the family. So, I am not too worried about any backwards study. Most scientists today, what with all the tools we have now, would not rely much on self-reported data as it is known to be inaccurate.