Hi everyone, To those who already have filled a delzicol prescription, it would be great if you could keep us informed as you switch over as to how the transition goes. I heard about this about a month ago, and already complained to the company, who refused to confirm or deny the existence of the switchover. My understanding is that there will be no generics anytime soon- I called the FDA to ask and there are no applications whatsoever to make a generic. Plus, here's this language from the Warner-Chilcott earnings call transcript: "Important to note, we continue to believe that the regulatory pathway for the approval of generic versions of ASACOL and now DELZICOL present a high bar."
I suspect replacing the phalate in the coating and having the coating still work properly is the problem going forward with a generic.
I transitioned easily over the years from Rowasa and Colazal to generics, but all of this has me very concerned. 9 asacol a day have kept 2/3s of my colon in remission for years- before that I was looking at a colectomy. After reading the instructions to basically take Delzicol on an empty stomach, I really wonder if the new coating is going to work that well. I haven't been able to find any human studies showing where the delzicol dissolves.
As for Asacol HD, it is not apparently bioequivalent to Asacol, as least as far as measurements of blood concentrations go, so one has to take more of it. I already get lots of reflux and a sore throat from asacol, and I am concerned that the bigger asacol HD tablets will aggravate this. I am also concerned that taking delzicol on an empty stomach will aggravate this.
Anyway, I seem to remember from that generic colazal thread that complaining to the company that made the brand caused them to change their minds and continue manufacturing it? I read it a long time ago so I could be wrong, but it seems to me it wouldn't hurt to call the company and complain about this.